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Bazedoxifene acetate
CAS No. : 198481-33-3
MCE 国际站：Bazedoxifene acetate
产品活性：Bazedoxifene acetate (TSE-424 acetate) 是一种有口服活性的，非甾体、选择性的雌激素受体调节剂 (SERM)，对 ERα 和 ERβ 作用的 IC50 值分别为 26 nM 和 99 nM，可用于骨质疏松症的研究。Bazedoxifene acetate 也是一种 IL-6/GP130 蛋白相互作用抑制剂，可用于胰腺癌的研究。
研究领域：Vitamin D Related/Nuclear Receptor
In Vitro: Bazedoxifene acetate is a small molecular GP130 inhibitor, which binds to GP130 D1 domain.
?Bazedoxifene acetate inhibits STAT3 phosphorylation induced by Il-6 and IL-11 in GP130/STAT3 pathway signaling.
?Bazedoxifene acetate (10 μM-20 μM; 2 hours) inhibits STAT3 Phosphorylation Induced by cytokines in human pancreatic cancer cells.
?Bazedoxifene acetate (5-20 μM; overnight) induces apoptosis in human pancreatic cancer cells.
?Bazedoxifene acetate inhibits STAT3 nuclear translocation induced by IL-6.
?Bazedoxifene acetate blocks the cells migration in pancreatic cancer cells by inhibition of GP130.
In Vivo: Bazedoxifene acetate (5 mg/kg; i.g.; daily, for 18 days) inhibits Capan-1 tumor growth in mouse model in vivo.
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