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Peramivir

CAS No. : 330600-85-6

MCE 国际站：Peramivir

产品活性：Peramivir 是一种的新型环戊烷神经氨酸酶 (novel cyclopentane neuraminidase) 流感病毒抑制剂。Peramivir 具有抗病毒活性和抗细胞因子作用，可用于新型冠状病毒肺炎的研究。

研究领域：NF-κB  |  MAPK/ERK Pathway  |  JAK/STAT Signaling  |  Stem Cell/Wnt

作用靶点：IKK  |  JNK  |  STAT  |  p38 MAPK  |  ERK

In Vitro: Peramivir (0.3125-40 μM, 4 h) has nontoxicity to macrophage.
Peramivir (2-10 μM, 6-12 h) inhibits cytokine release in LPS-induced hPBMCs.

In Vivo: Peramivir (20-60 mg/kg, Intraperitoneal injection, single dose) inhibits LPS-induced cytokine storm, attenuates acute lung injury and prolongs the survival in cytokine storm syndrome model mice.
Peramivir (75 mg/kg, Intramuscular injection, once a day for 7 days) rescued BALB scid mice from lethal challenge with BR/08 in immunocompromised murine models of infuenza B virus infection.

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