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5-Azacytidine
CAS No. : 320-67-2
MCE 国际站：5-Azacytidine
产品活性：5-Azacytidine (Azacitidine; 5-AzaC; Ladakamycin) 是胞苷核苷类似物，特异型抑制 DNA 甲基化。5-Azacytidine 与 DNA 结合共价捕获 DNA甲基转移酶 (DNA methyltransferases)，有益于逆转表观遗传变化。5-Azacytidine 诱导细胞自噬 (autophagy)。
研究领域：Stem Cell/Wnt | Cell Cycle/DNA Damage | Epigenetics | Anti-infection | Autophagy
作用靶点：Organoid | Nucleoside Antimetabolite/Analog | DNA Methyltransferase | Bacterial | Autophagy | Antibiotic
In Vitro: Unmethylated CpG islands associated with a variety of genes become partially or fully methylated in tumors and can be reactivated by 5-Azacytidine. 5-Azacytidine acts as weak inducers of erythroid differentiation of Friend erythroleukemia cells in the same concentration range where they affect DNA methyltransferase activity. 5-Azacytidine inhibits L1210 cells with ID50 and ID90 values of 0.019 and circa 0.15 μg/mL, respectively.
In Vivo: TdR-3H incorporation is significantly inhibited when the animals are exposed to 5-Azacitidine (100 mg/kg, i.p.) for 2 hr or longer.
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