FITC标记的端粒酶相关蛋白1抗体
产品名称： FITC标记的端粒酶相关蛋白1抗体
英文名称： Anti-TEP1/FITC
产品编号： HZ-1908R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： IF=1:50-200
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Rabbit Anti-TEP1/FITC Conjugated antibody
FITC标记的端粒酶相关蛋白1抗体
| 英文名称 | Anti-TEP1/FITC |
| 中文名称 | FITC标记的端粒酶相关蛋白1抗体 |
| 别 名 | Telomerase Associated pratein-1; TEP1; TLP1; TP1 TP-1; Telomerase protein component 1; Telomerase protein 1; p240; p80 telomerase homolog; TEP1_HUMAN; Telomerase associated protein 1; Telomerase protein component 1; TROVE domain family, member 1; TROVE1; VAULT2. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 神经生物学 信号转导 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, |
| 产品应用 | IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 290kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human TP-1 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: Telomerase is an RNA-dependent DNA polymerase that uses an RNA component to add telomeric repeat sequences at the ends of chromosomes. Besides the RNA component which serves as the template that specifies the telomeric repeat, the telomerase complex contains a reverse transcriptase protein (TRT) and various accessory proteins including the telomerase-associated protein 1 (TEP1). Telomerase activity is low in most somatic cells, causing the gradual shortening of telomeres which can ultimately lead to telomere fusion and cell death. High levels of telomerase activity are widely seen in cancerous cells and while recent experiments have suggested that telomerase may be a viable target in cancer therapy, expression levels of TEP1 do not correlate with malignancy. At least two isoforms of TP1 are known to exist. Function: Component of the telomerase ribonucleoprotein complex that is essential for the replication of chromosome termini. Also component of the ribonucleoprotein vaults particle, a multi-subunit structure involved in nucleo-cytoplasmic transport. Responsible for the localizing and stabilizing vault RNA (vRNA) association in the vault ribonucleoprotein particle. Binds to TERC (By similarity). Subunit: Component of the telomerase holoenzyme complex at least composed of TERT, DKC1, WRAP53/TCAB1, NOP10, NHP2, GAR1, TEP1, EST1A, POT1 and a telomerase RNA template component (TERC). Subcellular Location: Nucleus (Probable). Telomere. Tissue Specificity: Ubiquitous. Similarity: Contains 1 NACHT domain. Contains 4 TEP1 N-terminal repeats. Contains 1 TROVE domain. Contains 21 WD repeats. Database links: Entrez Gene: 7011 Human Entrez Gene: 21745 Mouse Entrez Gene: 64523 Rat SwissProt: Q99973 Human SwissProt: P97499 Mouse SwissProt: O08653 Rat Unigene: 508835 Human Unigene: 318736 Mouse Unigene: 5890 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
端粒酶是一种依赖于RNA的DNA聚合酶，使用RNA成分在染色体末端添加端粒重复序列。除了作为端粒重复序列模板的RNA组分外，端粒酶复合物还含有逆转录酶蛋白（TRT）和各种辅助蛋白，包括端粒酶相关蛋白1（TEP1）。端粒酶活性在大多数体细胞中较低，导致端粒逐渐缩短，最终可能导致端粒融合和细胞死亡。端粒酶活性在癌细胞中广泛存在，而最近的实验表明端粒酶可能是癌症治疗中可行的靶点，TEP1的表达水平与恶性肿瘤无关。已知至少有两种TP1异构体存在。