ESPL1 polyclonal antibody
产品名称： ESPL1 polyclonal antibody
英文名称： ESPL1 polyclonal antibody
产品编号： PAB12431
产品价格： null
产品产地： 台湾
品牌商标： Abnova
更新时间： null
使用范围：
亚诺法生技股份有限公司（Abnova)
- 联系人 :
- 地址 : 台湾台北市内湖区洲子街 108 号 9 楼
- 邮编 : 11493
- 所在区域 : 台湾
- 电话 : +886-920**1152 点击查看
- 传真 : 点击查看
- 邮箱 : sales@abnova.com.tw
- Specification
- Product Description:
- Rabbit polyclonal antibody raised against synthetic peptide of ESPL1.
- Immunogen:
- A synthetic peptide corresponding to amino acids 1400-1500 of human ESPL1.
- Host:
- Rabbit
- Reactivity:
- Human
- Specificity:
- This antibody detects both isoforms of Separase.
- Form:
- Liquid
- Storage Buffer:
- In Tris-citrate/phosphate buffer, pH 7.0-8.0 (0.1% sodium azide)
- Storage Instruction:
- Store at 4°C. Do not freeze.
- Quality Control Testing:
- Antibody Reactive Against Synthetic Peptide.
- Recommend Usage:
- Western Blot (2 mg/mL)
The optimal working dilution should be determined by the end user.
- Note:
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Publication Reference
- 1.
- Processing, localization, and requirement of human separase for normal anaphase progression.
Chestukhin A, Pfeffer C, Milligan S, DeCaprio JA, Pellman D.Proc Natl Acad Sci U S A. 2003 Apr 15;100(8):4574-9. Epub 2003 Apr 2.
- Entrez GeneID:
- 9700
- Protein Accession#:
- Q14674
- Gene Name:
- ESPL1
- Gene Alias:
- ESP1,FLJ46492,KIAA0165,SEPARASE,SEPARIN
- Gene Description:
- extra spindle pole bodies homolog 1 (S. cerevisiae)
- Omim ID:
- 604143
- Gene Ontology:
- Hyperlink
- Gene Summary:
- Stable cohesion between sister chromatids before anaphase and their timely separation during anaphase are critical for chromosome inheritance. In vertebrates, sister chromatid cohesion is released in 2 steps via distinct mechanisms. The first step involves phosphorylation of STAG1 (MIM 604358) or STAG2 (MIM 604359) in the cohesin complex. The second step involves cleavage of the cohesin subunit SCC1 (RAD21; MIM 606462) by ESPL1, or separase, which initiates the final separation of sister chromatids (Sun et al., 2009 [PubMed 19345191]).[supplied by OMIM
- Other Designations:
- extra spindle poles like 1,separin, separase
- Gene Pathway