CLCA4,钙激活氯离子通道4蛋白抗体

产品编号HZ-15511R
英文名称CLCA4
中文名称钙激活氯离子通道4蛋白抗体
别 名CaCC-2; Calcium-activated chloride channel family member 4; Calcium-activated chloride channel protein 2; Calcium-activated chloride channel regulator 4; Clca4; CLCA4_HUMAN; hCaCC-2; hCLCA4; calcium-activated chloride channel regulator 4 precursor; Parturition-related protein PRP3; Clca6; Prp3.
说 明 书0.1ml 0.2ml
研究领域细胞生物 免疫学 信号转导 新陈代谢
抗体来源Rabbit
克隆类型Polyclonal
交叉反应Human, Mouse, Rat, Dog, Pig, Cow, Horse, Sheep,
CLCA4,钙激活氯离子通道4蛋白抗体产品应用WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量99、101kDa
性 状Lyophilized or Liquid
浓 度1mg/1ml
免 疫 原KLH conjugated synthetic peptide derived from human CLCA4
亚 型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
CLCA4,钙激活氯离子通道4蛋白抗体PubMedPubMed
产品介绍background:
The protein encoded by this gene belongs to the calcium sensitive chloride conductance protein family. To date, all members of this gene family map to the same site on chromosome 1p31-p22 and share high degrees of homology in size, sequence and predicted structure, but differ significantly in their tissue distributions. Alternative splicing results in multiple transcript variants, only one of which is thought to be protein coding. [provided by RefSeq, Dec 2008].

Function:
May be involved in mediating calcium-activated chloride conductance.

Subcellular Location:
Cell membrane; Single-pass membrane protein. Apical cell membrane. Secreted. Note=The C-terminus 30 kDa form is anchored to the membrane. The N-terminus 110 kDa form is released from the membrane triggered by an unknown stimulus. Associated with the microvilli of non-goblet cell enterocytes in the small and large intestine. Co-localizes with CFTR.

Tissue Specificity:
Expressed in the non-goblet intestinal cells. High levels in intestine and stomach, and lower levels in eye, liver and spleen. Increasing expression from the duodenum to the ilium, and decreasing expression to the colon. Isoform 2 is expressed in intestine and stomach but at lower levels than isoform 1.

Post-translational modifications:
N-Glycosylated.
Processed at a monobasic residue to yield a larger N-terminal and a smaller C-terminal cleavage products of 90 to 110 and 30 to 35 kDa, respectively.

Similarity:
Belongs to the CLCR family.
Contains 1 VWFA domain.

Gene ID:
22802

Database links:
Entrez Gene: 22802 Human
SwissProt: Q14CN2 Human
Unigene: 567422 Human

CLCA4,钙激活氯离子通道4蛋白抗体Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.