FITC标记的铜转运蛋白2抗体
产品名称： FITC标记的铜转运蛋白2抗体
英文名称： Anti-COPT2/FITC
产品编号： HZ-13981R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： ICC=1:50-200 IF=1:50-200
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Rabbit Anti-COPT2/FITC Conjugated antibody
FITC标记的铜转运蛋白2抗体
| 英文名称 | Anti-COPT2/FITC |
| 中文名称 | FITC标记的铜转运蛋白2抗体 |
| 别 名 | AI604396; Copper transporter 2; COPT2; COPT2_HUMAN; CTR2; hCTR2; MGC117640; Probable low affinity copper uptake protein 2; RP23 64F17.2; SLC31A2; Solute carrier family 31 member 2; Solute carrier family 31, member 2. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 细胞生物 信号转导 转运蛋白 新陈代谢 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Rabbit, |
| 产品应用 | ICC=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 16kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human COPT2 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: The activity of a diverse subset of enzymes relies on the essential nutrient copper to perform important processes including signaling to the transcription and protein trafficking machinery, oxidative phosphorylation, iron mobilization, neuropeptide maturation, and normal development. Copper uptake requires tight regulation to ensure that sufficient copper is present in the cell to drive vital cellular processes, while avoiding the accumulation of copper to toxic levels. The copper transporter 2 (COPT2), also designated CTR2 or Solute carrier family 31 member 2 (SLC31A2), is a 143 amino acid protein mediates the uptake of copper in mammalian cells. COPT2 has been shown to localize to the plasma membrane, endosomes and lysosomes, where it plays a role in maintaining copper homeostasis. COPT2 also mediates the uptake of the chemotherapeutic drugs cisplatin and carboplatin and may modulate the sensitivity and toxicity of these drugs. Function: Involved in low-affinity copper uptake. Subcellular Location: Membrane. Tissue Specificity: Ubiquitous. Similarity: Belongs to the copper transporter (Ctr) (TC 1.A.56) family. SLC31A subfamily. Database links: Entrez Gene: 1318 Human Entrez Gene: 20530 Mouse Omim: 603088 Human SwissProt: O15432 Human SwissProt: Q9CPU9 Mouse Unigene: 24030 Human Unigene: 292539 Mouse Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
多种酶的活性依赖于必需的营养铜来执行重要过程，包括转录和蛋白质运输机制的信号、氧化磷酸化、铁动员、神经肽成熟和正常发育。铜的摄取需要严格的调节，以确保细胞内有足够的铜来驱动重要的细胞过程，同时避免铜积累到毒性水平。铜转运蛋白2（COPT2），也称为CTR2或溶质载体家族31成员2（SLC31A2），是一种介导哺乳动物细胞摄取铜的143个氨基酸蛋白。COPT2已显示定位于质膜、内切体和溶酶体，在维持铜稳态中发挥作用。COPT2还介导化疗药物顺铂和卡铂的摄取，并可能调节这些药物的敏感性和毒性。