Gliomedin,神经胶质蛋白(肝癌相关基因2)抗体

产品编号HZ-11032R
英文名称Gliomedin
中文名称神经胶质蛋白(肝癌相关基因2)抗体
别 名CANCER RELATED GENE LIVER 2; Cancer related gene-Liver 2; CLOM; collomin; Colm (gene name); COLM; Colmedin; CRG L2; FLJ23917; Gldn (gene name); UNC 112; GLDN_HUMAN.
说 明 书0.1ml 0.2ml
研究领域神经生物学 信号转导 细胞粘附分子 细胞骨架
抗体来源Rabbit
克隆类型Polyclonal
交叉反应 Human, Mouse, Rat, Dog, Pig, Cow, Horse, Sheep,
Gliomedin,神经胶质蛋白(肝癌相关基因2)抗体产品应用WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量59kDa
细胞定位细胞膜
性 状Lyophilized or Liquid
浓 度1mg/1ml
免 疫 原KLH conjugated synthetic peptide derived from human Gliomedin/COLM
亚 型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
Gliomedin,神经胶质蛋白(肝癌相关基因2)抗体PubMedPubMed
产品介绍background:
Gliomedin is a 551 amino acid protein encoded by the human gene GLDN. Gliomedin is thought to play a role in the formation of the nodes of Ranvier along myelinated axons. Accumulation of Na+ channels at the nodes of Ranvier is a prerequisite for saltatory conduction. In peripheral nerves, clustering of these channels along the axolemma is regulated by myelinating Schwann cells through an unknown mechanism. Gliomedin is a glial ligand for Neurofascin and NrCAM, two axonal immunoglobulin cell adhesion molecules that are associated with Na+ channels at the nodes of Ranvier. Gliomedin is expressed by myelinating Schwann cells and accumulates at the edges of each myelin segment during development, where it aligns with the forming nodes. Gliomedin is a single-pass type II membrane protein localized to the nodes of Ranvier and is specifically expressed in spinal cord, brain, placenta and sciatic nerve. It is more abundant in peripheral than central nervous system.

Function:
Gliomedin is a member of the collagen superfamily, it is a glial ligand for neurofascin and NrCAM, two axonal immunoglobulin cell adhesion molecules that are associated with Na+ channels at the nodes of Ranvier. Gliomedin provides a glial cue for the formation of peripheral nodes of Ranvier. Gliomedin is expressed by myelinating Schwann cells and accumulates at the edges of each myelin segment during development, where it aligns with the forming nodes of ranvier. Eliminating the expression of gliomedin or the addition of a soluble extracellular domain of neurofascin to myelinating cultures abolishes node formation. Gliomedin is expressed in the PNS nodes of ranvier, but not in the CNS nodes of ranvier. Gliomedin also displays high expression in murine and human hepatocellular carcinomas (HCC). Its restricted expression in normal tissues and unique early upregulation during tumor development make it an excellent candidate as a new clinical marker of HCC.

Subunit:
Interacts with NFASC/neurofascin and NRCAM.

Subcellular Location:
Cell membrane; Single-pass type II membrane protein. Note=Localizes to the nodes of Ranvier.

Gliomedin,神经胶质蛋白(肝癌相关基因2)抗体Tissue Specificity:
Specifically expressed in spinal cord, brain, placenta and sciatic nerve. More abundant in peripheral than central nervous system.

Similarity:
Contains 2 collagen-like domains.
Contains 1 olfactomedin-like domain.

Gene ID:
342035

Database links:
Entrez Gene: 342035 Human
Entrez Gene: 235379 Mouse
Entrez Gene: 315675 Rat
Omim: 608603 Human
SwissProt: Q6ZMI3 Human
SwissProt: Q7Z359 Human
SwissProt: Q80ZC5 Mouse
SwissProt: Q8BMF8 Mouse
SwissProt: Q80WL1 Rat
Unigene: 526441 Human
Unigene: 123549 Mouse
Unigene: 38054 Rat

Gliomedin,神经胶质蛋白(肝癌相关基因2)抗体Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.