FITC标记的脑型肉碱棕榈酰转移酶1C抗体
产品名称： FITC标记的脑型肉碱棕榈酰转移酶1C抗体
英文名称： Anti-Cpt1c/FITC
产品编号： HZ-11416R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： ICC=1:50-200 IF=1:50-200
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Rabbit Anti-Cpt1c/FITC Conjugated antibody
FITC标记的脑型肉碱棕榈酰转移酶1C抗体
| 产品编号 | bs-11416R-FITC |
| 英文名称 | Anti-Cpt1c/FITC |
| 中文名称 | FITC标记的脑型肉碱棕榈酰转移酶1C抗体 |
| 别 名 | CPT1-C; Carnitine acyltransferase like protein 1; Carnitine acyltransferase like protein1; Carnitine O palmitoyltransferase I, brain isoform; Carnitine palmitoyltransferase 1, brain; Carnitine palmitoyltransferase 1C; Carnitine palmitoyltransferase I related C; Carnitine palmitoyltransferase1C; CAT L1; CATL 1; CATL1; CPT 1 like pseudogene; Cpt 1c; CPT 1P; CPT I C; Cpt1 c; CPT1 like pseudogene; CPT1P ; CPTIC.CPT1C_HUMAN |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 肿瘤 心血管 细胞生物 神经生物学 信号转导 内分泌病 线粒体 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Dog, Pig, Cow, Horse, |
| 产品应用 | ICC=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 88kDa |
| 细胞定位 | 细胞膜 线粒体 |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human Cpt1c (121-170aa) |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: The Cpt1 family of proteins are outer mitochondrial membrane proteins that regulate the entry into, and oxidation of fatty acids by, mitochondria. Malonyl-CoA, an intermediate in fatty acid synthesis, has been implicated as a regulatory component of the energy sensing system that feeds into hypothalmic neurons to impart energy homeostasis. Malonyl-CoA levels in the hypothalamus are dynamically regulated by fasting and feeding, altering subsequent feeding behaviour. Cpt1c, the brain-specific carnitine O-palmitoyltransferase 1, is thought to relay information about malonyl-CoA levels in hypothalamic neurons that express orexigenic and anorexigenic neuropeptides that regulate food intake and peripheral energy expenditure. Unlike other Cpt1 proteins, Cpt1c binds Malonyl-CoA but does not catalyse the transfer of the malonyl group from CoA to carnitine. Subcellular Location: Mitochondrion outer membrane; Multi-pass membrane protein Tissue Specificity: Expressed predominantly in brain and testis. Similarity: Belongs to the carnitine/choline acetyltransferase family. Database links: UniProtKB/Swiss-Prot: Q8TCG5.1 Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
蛋白质的CTP1家族是线粒体线粒体膜蛋白，通过线粒体调节脂肪酸的进入和氧化。Malonyl CoA，脂肪酸合成中的一个中间体，被认为是能量敏感系统的调节成分，它能进入下丘脑神经元以赋予能量稳态。下丘脑中丙二酰辅酶A水平受禁食和摄食的动态调节，改变随后的摄食行为。CTP1C，脑特异性肉碱O-棕榈酰基转移酶1，被认为是传达有关丙二酰辅酶A水平的信息，下丘脑神经元表达食欲原和厌食神经肽，调节食物摄入量和外周能量消耗。与其他CTP1蛋白不同，CTP1C结合丙二酰辅酶A，但不催化丙二酰基从CoA转移到肉碱。