WASL polyclonal antibody
产品名称： WASL polyclonal antibody
英文名称： WASL polyclonal antibody
产品编号： PAB7887
产品价格： null
产品产地： 台湾
品牌商标： Abnova
更新时间： null
使用范围：
亚诺法生技股份有限公司（Abnova)
- 联系人 :
- 地址 : 台湾台北市内湖区洲子街 108 号 9 楼
- 邮编 : 11493
- 所在区域 : 台湾
- 电话 : +886-920**1152 点击查看
- 传真 : 点击查看
- 邮箱 : sales@abnova.com.tw
- Specification
- Product Description:
- Rabbit polyclonal antibody raised against synthetic peptide of WASL.
- Immunogen:
- A synthetic peptide (conjugated with KLH) corresponding to N-terminus of human WASL.
- Host:
- Rabbit
- Reactivity:
- Human, Mouse, Rat
- Specificity:
- This N-WASP peptide sequence is 100% homologous to rat and mouse N-WASP, and has low homology to the corresponding region in the human WASP.
- Form:
- Liquid
- Storage Buffer:
- In PBS (50% glycerol, 1 mg/mL BSA, 0.05% sodium azide)
- Storage Instruction:
- Store at -20°C.
Aliquot to avoid repeated freezing and thawing.
- Quality Control Testing:
- Antibody Reactive Against Synthetic Peptide.
- Recommend Usage:
- ELISA (1:2000)
Western Blot (1:500)
The optimal working dilution should be determined by the end user.
- Note:
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Publication Reference
- 1.
- Phosphorylation of the WASP-VCA domain increases its affinity for the Arp2/3 complex and enhances actin polymerization by WASP.
Cory GO, Cramer R, Blanchoin L, Ridley AJ.Mol Cell. 2003 May;11(5):1229-39.
- 2.
- Regulation of actin filament network formation through ARP2/3 complex: activation by a diverse array of proteins.
Higgs HN, Pollard TD.Annu Rev Biochem. 2001;70:649-76.
- Entrez GeneID:
- 8976
- Gene Name:
- WASL
- Gene Alias:
- DKFZp779G0847,MGC48327,N-WASP,NWASP
- Gene Description:
- Wiskott-Aldrich syndrome-like
- Omim ID:
- 605056
- Gene Ontology:
- Hyperlink
- Gene Summary:
- The Wiskott-Aldrich syndrome (WAS) family of proteins share similar domain structure, and are involved in transduction of signals from receptors on the cell surface to the actin cytoskeleton. The presence of a number of different motifs suggests that they are regulated by a number of different stimuli, and interact with multiple proteins. Recent studies have demonstrated that these proteins, directly or indirectly, associate with the small GTPase, Cdc42, known to regulate formation of actin filaments, and the cytoskeletal organizing complex, Arp2/3. The WASL gene product is a homolog of WAS protein, however, unlike the latter, it is ubiquitously expressed and shows highest expression in neural tissues. It has been shown to bind Cdc42 directly, and induce formation of long actin microspikes. [provided by RefSeq
- Other Designations:
- Wiskott-Aldrich syndrome gene-like,Wiskott-Aldrich syndrome gene-like protein,neural Wiskott-Aldrich syndrome protein