FITC标记的精子发生相关蛋白20抗体
产品名称： FITC标记的精子发生相关蛋白20抗体
英文名称： Anti-SPATA20/FITC
产品编号： HZ-17625R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： ICC=1:50-200 IF=1:50-200
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Rabbit Anti-SPATA20/FITC Conjugated antibody
FITC标记的精子发生相关蛋白20抗体
| 英文名称 | Anti-SPATA20/FITC |
| 中文名称 | FITC标记的精子发生相关蛋白20抗体 |
| 别 名 | SPATA20; Sperm protein SSP411; Sperm-specific protein 411; Spermatogenesis associated 20; Spermatogenesis-associated protein 20; SPT20_HUMAN; Ssp411; Tisp78; Transcript increased in spermiogenesis 78. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 细胞生物 发育生物学 干细胞 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Dog, Pig, Cow, Horse, Sheep, Guinea Pig, |
| 产品应用 | ICC=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 58kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human SPATA20 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: SPATA20 is a 786 amino acid protein that may be involved in fertility regulation. SPATA20 is expressed in testis in an age dependent manner and localizes to round and elongated spermatids. SPATA20 contains a conserved thioredoxin-like domain near the N-terminus region and exists as four isoforms produced by alternative splicing events. SPATA20 is encoded by a gene located on human chromosome 17, which comprises over 2.5% of the human genome and encodes over 1,200 genes. Two key tumor suppressor genes are associated with chromosome 17, namely, p53 and BRCA1. Tumor suppressor p53 is necessary for maintenance of cellular genetic integrity by moderating cell fate through DNA repair versus cell death. Malfunction or loss of p53 expression is associated with malignant cell growth and Li-Fraumeni syndrome. Like p53, BRCA1 is directly involved in DNA repair, though specifically it is recognized as a genetic determinant of early onset breast cancer and predisposition to cancers of the ovary, colon, prostate gland and fallopian tubes. Function: May play a role in fertility regulation. Subcellular Location: Secreted. Database links: Entrez Gene: 511363 Cow Entrez Gene: 491082 Dog Entrez Gene: 100714104 Guinea pig Entrez Gene: 100069987 Horse Entrez Gene: 64847 Human Entrez Gene: 217116 Mouse Entrez Gene: 100286812 Pig Entrez Gene: 360604 Rat Omim: 613939 Human SwissProt: Q8TB22 Human SwissProt: Q80YT5 Mouse SwissProt: Q6T393 Rat Unigene: 103147 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
SPATA20是一种可能参与育性调控的786氨基酸蛋白。SpATA20在睾丸中以年龄依赖的方式表达，并定位为圆形和细长的精子细胞。SPATA20在N-末端附近含有一个保守的硫氧还蛋白样结构域，并且以四种异构体形式存在，这些异构体由不同的剪接事件产生。SPATA20由位于人类染色体17上的基因编码，该基因占人类基因组的2.5%以上，编码1200多个基因。两个关键的肿瘤抑制基因与17号染色体相关，即p53和BRCA1。肿瘤抑制因子p53通过DNA修复和细胞死亡来调节细胞命运，从而维持细胞遗传完整性。p53表达的异常或丢失与恶性细胞生长和Li Fraumeni综合征有关。与p53一样，BRCA1直接参与DNA修复，尽管它特别被认为是早期发病的乳腺癌和易患卵巢、结肠、前列腺和输卵管癌的遗传决定因素。