PPARD (Human) Recombinant Protein (Q01)
产品名称: PPARD (Human) Recombinant Protein (Q01)
英文名称: PPARD (Human) Recombinant Protein (Q01)
产品编号: H00005467-Q01
产品价格: 0
产品产地: 台湾
品牌商标: Abnova
更新时间: null
使用范围: null
亚诺法生技股份有限公司(Abnova)
- 联系人 :
- 地址 : 台湾台北市内湖区洲子街 108 号 9 楼
- 邮编 : 11493
- 所在区域 : 台湾
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- 邮箱 : sales@abnova.com.tw
- Specification
- Product Description:
- Human PPARD partial ORF ( NP_006229, 56 a.a. - 165 a.a.) recombinant protein with GST-tag at N-terminal.
- Sequence:
- DQLQMGCDGASCGSLNMECRVCGDKASGFHYGVHACEGCKGFFRRTIRMKLEYEKCERSCKIQKKNRNKCQYCRFQKCLALGMSHNAIRFGRMPEAEKRKLVAGLTANEG
- Theoretical MW (kDa):
- 37.84
- Preparation Method:
- in vitro wheat germ expression system
- Purification:
- Glutathione Sepharose 4 Fast Flow
- Storage Buffer:
- 50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.
- Storage Instruction:
- Store at -80°C. Aliquot to avoid repeated freezing and thawing.
- Quality Control Testing:
- 12.5% SDS-PAGE Stained with Coomassie Blue.
- Note:
- Best use within three months from the date of receipt of this protein.
- MSDS:
- Download
- Application Image
- Enzyme-linked Immunoabsorbent Assay
- Western Blot (Recombinant protein)
- Antibody Production
- Protein Array
- Entrez GeneID:
- 5467
- GeneBank Accession#:
- NM_006238
- Protein Accession#:
- NP_006229
- Gene Name:
- PPARD
- Gene Alias:
- FAAR,MGC3931,NR1C2,NUC1,NUCI,NUCII,PPAR-beta,PPARB
- Gene Description:
- peroxisome proliferator-activated receptor delta
- Omim ID:
- 600409
- Gene Ontology:
- Hyperlink
- Gene Summary:
- This gene encodes a member of the peroxisome proliferator-activated receptor (PPAR) family. PPARs are nuclear hormone receptors that bind peroxisome proliferators and control the size and number of peroxisomes produced by cells. PPARs mediate a variety of biological processes, and may be involved in the development of several chronic diseases, including diabetes, obesity, atherosclerosis, and cancer. This protein is a potent inhibitor of ligand-induced transcription activity of PPAR alpha and PPAR gamma. It may function as an integrator of transcription repression and nuclear receptor signaling. The expression of this gene is found to be elevated in colorectal cancer cells. The elevated expression can be repressed by adenomatosis polyposis coli (APC), a tumor suppressor protein related to APC/beta-catenin signaling pathway. Knockout studies in mice suggested the role of this protein in myelination of the corpus callosum, lipid metabolism, and epidermal cell proliferation. [provided by RefSeq
- Other Designations:
- OTTHUMP00000016256,nuclear hormone receptor 1,peroxisome proliferative activated receptor, delta
- Related Disease
- Adenocarcinoma
- Adenoma
- Alzheimer Disease
- Alzheimer disease
- Atherosclerosis
- Atherosclerosis
- Biliary Tract Neoplasms
- Bipolar Disorder
- Body Weight
- Calcinosis
- Carcinoma, Non-Small-Cell Lung
- Cardiovascular Diseases
- Colon cancer
- Colonic Neoplasms
- Colorectal Neoplasms
- Coronary Artery Disease
- Coronary Disease
- Diabetes Complications
- Diabetes Mellitus, Type 2