FITC标记的TPIT蛋白抗体
产品名称： FITC标记的TPIT蛋白抗体
英文名称： Anti-TPIT/FITC
产品编号： HZ-17167R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： ICC=1:50-200 IF=1:50-200
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Rabbit Anti-TPIT/FITC Conjugated antibody
FITC标记的TPIT蛋白抗体
| 英文名称 | Anti-TPIT/FITC |
| 中文名称 | FITC标记的TPIT蛋白抗体 |
| 别 名 | DJ747L4.1; T Box 19; T box factor, pituitary; T box protein 19; T box transcription factor TBX19; T box transcription factor TBX19; TBS 19; TBS19; TBX19; TPIT. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 细胞生物 转录调节因子 表观遗传学 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Chicken, Dog, Pig, Cow, Horse, Rabbit, Chimpanzee, |
| 产品应用 | ICC=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 48kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human TPIT |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: This gene is a member of a phylogenetically conserved family of genes that share a common DNA-binding domain, the T-box. T-box genes encode transcription factors involved in the regulation of developmental processes. Mutations in this gene were found in patients with isolated deficiency of pituitary POMC-derived ACTH, suggesting an essential role for this gene in differentiation of the pituitary POMC lineage. ACTH deficiency is characterized by adrenal insufficiency symptoms such as weight loss, lack of appetite (anorexia), weakness, nausea, vomiting, and low blood pressure. [provided by RefSeq, Jul 2008] Function: Tpit (TBX19, T box 19) is a highly cell-restricted transcription factor belonging to the T-Box family. T box 19 is required for pro-opeiomelanocortin (POMC) gene expression and differentiation of corticotroph and melanotroph cells. Tpit gene mutations have been shown to be directly correlated to pituitary adrenocorticotropin (ACTH) deficiencies. Tpit functions as a transcriptional activator by recruiting the p160 family of coactivators. Subcellular Location: Nuclear Similarity: Contains 1 T-box DNA-binding domain. Database links: Entrez Gene: 395793 Chicken Entrez Gene: 514352 Cow Entrez Gene: 449029 Dog Entrez Gene: 9095 Human Entrez Gene: 83993 Mouse Entrez Gene: 304935 Rat Omim: 604614 Human SwissProt: O60806 Human SwissProt: Q99ME7 Mouse Unigene: 190649 Mouse Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
该基因是一个系统发育保守的基因家族成员，共享一个共同的DNA结合结构域，即T盒。T-box基因编码参与发育过程调控的转录因子。在孤立性垂体POMC衍生ACTH缺陷的患者中发现了该基因的突变，提示该基因在垂体POMC谱系分化中起重要作用。ACTH缺乏的特征是肾上腺功能不全症状如体重减轻，