TLR2 (N-term) Peptide
产品名称： TLR2 (N-term) Peptide
英文名称： TLR2 (N-term) Peptide
产品编号： P0502
产品价格： 0
产品产地： 台湾
品牌商标： Abnova
更新时间： null
使用范围： null
亚诺法生技股份有限公司（Abnova)
- 联系人 :
- 地址 : 台湾台北市内湖区洲子街 108 号 9 楼
- 邮编 : 11493
- 所在区域 : 台湾
- 电话 : +886-920**1152 点击查看
- 传真 : 点击查看
- 邮箱 : sales@abnova.com.tw
- Specification
- Product Description:
- Rabbit polyclonal antibody raised against synthetic peptide of TLR2.
- Immunogen:
- A synthetic peptide (conjugated with KLH) corresponding to N-terminus of human TLR2.
- Host:
- Rabbit
- Reactivity:
- Human
- Form:
- Liquid
- Purification:
- Protein G purification
- Storage Buffer:
- In PBS (0.09% sodium azide)
- Storage Instruction:
- Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.
- Recommend Usage:
- ELISA (1:1000)
Western Blot (1:50-100)
Immunohistochemistry (1:50-100)
Flow cytometry (1:10-50)
The optimal working dilution should be determined by the end user.
- Note:
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Publication Reference
- 1.
- Importance of extra- and intracellular domains of TLR1 and TLR2 in NFkappa B signaling.
Sandor F, Latz E, Re F, Mandell L, Repik G, Golenbock DT, Espevik T, Kurt-Jones EA, Finberg RW.J Cell Biol. 2003 Sep 15;162(6):1099-110.
- 2.
- Cellular recognition of tri-/di-palmitoylated peptides is independent from a domain encompassing the N-terminal seven leucine-rich repeat (LRR)/LRR-like motifs of TLR2.
Meng G, Grabiec A, Vallon M, Ebe B, Hampel S, Bessler W, Wagner H, Kirschning CJ.J Biol Chem. 2003 Oct 10;278(41):39822-9. Epub 2003 Jul 14.
- 3.
- Airway epithelia regulate expression of human beta-defensin 2 through Toll-like receptor 2.
Wang X, Zhang Z, Louboutin JP, Moser C, Weiner DJ, Wilson JM.FASEB J. 2003 Sep;17(12):1727-9. Epub 2003 Jul 3.
- Applications
- Western Blot (Cell lysate)
- Western blot analysis of K-562 cell lysate (35 ug/lane) with TLR2 polyclonal antibody (Cat # PAB3542).
- Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
- Formalin-fixed and paraffin-embedded human cancer tissue reacted with TLR2 polyclonal antibody (Cat # PAB3542) , which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. This data demonstrates the use of this antibody for immunohistochemistry ; clinical relevance has not been evaluated. BC = breast carcinoma.
- Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
- Formalin-fixed and paraffin-embedded human lung carcinomareacted with TLR2 polyclonal antibody (Cat # PAB3542), which was peroxidase-conjugated to the secondary antibody, followed by AEC staining.
This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.
- Entrez GeneID:
- 7097
- Protein Accession#:
- O60603
- Gene Name:
- TLR2
- Gene Alias:
- CD282,TIL4
- Gene Description:
- toll-like receptor 2
- Gene Ontology:
- Hyperlink
- Gene Summary:
- The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This gene is expressed most abundantly in peripheral blood leukocytes, and mediates host response to Gram-positive bacteria and yeast via stimulation of NF-kappaB. [provided by RefSeq
- Other Designations:
- toll/interleukin 1 receptor-like 4
- Gene Pathway
- Related Disease
- Acute Disease
- Aggressive Periodontitis
- Agricultural Workers' Diseases
- Amyloidosis
- Arthritis, Reactive
- Arthritis, Rheumatoid
- Aspergillosis
- Aspergillosis, Allergic Bronchopulmonary
- Asthma
- Asthma
- Atherosclerosis
- Atherosclerosis
- Bacteremia
- Bacterial Infections
- Bacteriuria
- Behcet Syndrome
- Birth Weight
- Breast Neoplasms
- Bronchial Hyperreactivity