FITC标记的叶酸受体α/α-FR 抗体
产品名称： FITC标记的叶酸受体α/α-FR 抗体
英文名称： Anti-Folate Receptor alpha/FITC
产品编号： HZ-7370R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： ICC=1:50-200 IF=1:50-200
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Rabbit Anti-Folate Receptor alpha/FITC Conjugated antibody
FITC标记的叶酸受体α/α-FR 抗体
| 英文名称Anti-Folate Receptor alpha/FITC中文名称FITC标记的叶酸受体α/α-FR 抗体别 名adult; Adult folate binding protein; Adult folate-binding protein; FBP; Folate Receptor 1 Adult; Folate receptor 1; Folate Receptor 1 Precursor; Folate receptor adult; Folate receptor alpha; Folate receptor; FOLR; FOLR1; FOLR1_HUMAN; FR alpha; FR-alpha; FRalpha; KB cells FBP; MOV18; Ovarian cancer associated antigen; Ovarian tumor associated antigen; Ovarian tumor associated antigen MOv18; Ovarian tumor-associated antigen MOv18. 规格价格100ul/2980元 购买 大包装/询价说 明 书100ul 研究领域肿瘤 细胞生物 信号转导 细胞膜受体 抗体来源Rabbit克隆类型Polyclonal交叉反应Human, Rat, Cow, Rabbit, Sheep, 产品应用ICC=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.分 子 量27kDa性 状Lyophilized or Liquid浓 度1mg/ml免 疫 原KLH conjugated synthetic peptide derived from human Folate Receptor alpha亚 型IgG纯化方法affinity purified by Protein A储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.产品介绍background: The protein encoded by this gene is a member of the folate receptor family. Members of this gene family bind folic acid and its reduced derivatives, and transport 5-methyltetrahydrofolate into cells. This gene product is a secreted protein that either anchors to membranes via a glycosyl-phosphatidylinositol linkage or exists in a soluble form. Mutations in this gene have been associated with neurodegeneration due to cerebral folate transport deficiency. Due to the presence of two promoters, multiple transcription start sites, and alternative splicing, multiple transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Oct 2009] Function: Binds to folate and reduced folic acid derivatives and mediates delivery of 5-methyltetrahydrofolate to the interior of cells. Subcellular Location: Cell membrane. Secreted. Tissue Specificity: Exclusively expressed in tissues of epithelial origin. Expression is increased in malignant tissues. Expressed in kidney, lung and cerebellum. Post-translational modifications: Eight disulfide bonds are present. The secreted form is derived from the membrane-bound form either by cleavage of the GPI anchor, or/and by proteolysis catalyzed by a metalloprotease. DISEASE: Defects in FOLR1 are the cause of neurodegeneration due to cerebral folate transport deficiency (NCFTD) [MIM:613068]. NCFTD is an autosomal recessive disorder resulting from brain-specific folate deficiency early in life. Onset is apparent in late infancy with severe developmental regression, movement disturbances, epilepsy, and leukodystrophy. Note=Recognition and diagnosis of this disorder is critical because folinic acid therapy can reverse the clinical symptoms and improve brain abnormalities and function. Similarity: Belongs to the folate receptor family. Database links: Entrez Gene: 2348 Human Omim: 136430 Human SwissProt: P15328 Human Unigene: 73769 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
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由该基因编码的蛋白质是叶酸受体家族的成员。该基因家族成员结合叶酸及其还原衍生物，并将5-甲基四氢叶酸转运到细胞中。这种基因产物是一种分泌蛋白，它通过糖基-磷脂酰肌醇键锚定在膜上，或者以可溶性形式存在。该基因的突变与脑叶酸转运缺陷引起的神经退行性变有关。由于存在两个启动子、多个转录起始位点和选择性剪接，已经发现该基因的多个编码相同蛋白的转录变体。[ RefSeq，OCT 2009提供]