MDM2 (phospho S166) polyclonal antibody
产品名称： MDM2 (phospho S166) polyclonal antibody
英文名称： MDM2 (phospho S166) polyclonal antibody
产品编号： PAB4920
产品价格： null
产品产地： 台湾
品牌商标： Abnova
更新时间： null
使用范围：
亚诺法生技股份有限公司（Abnova)
- 联系人 :
- 地址 : 台湾台北市内湖区洲子街 108 号 9 楼
- 邮编 : 11493
- 所在区域 : 台湾
- 电话 : +886-920**1152 点击查看
- 传真 : 点击查看
- 邮箱 : sales@abnova.com.tw
- Specification
- Product Description:
- Rabbit polyclonal antibody raised against synthetic phosphopeptide of MDM2.
- Immunogen:
- Synthetic phosphopeptide (conjugated with KLH) corresponding to residues surrounding S166 of human MDM2.
- Host:
- Rabbit
- Reactivity:
- Human
- Form:
- Liquid
- Purification:
- Protein A purification
- Storage Buffer:
- In PBS (0.09% sodium azide)
- Storage Instruction:
- Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.
- Recommend Usage:
- ELISA (1:1000)
Dot Blot (1:500)
The optimal working dilution should be determined by the end user.
- Note:
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Publication Reference
- 1.
- Synoviocyte stimulation by the LFA-1-intercellular adhesion molecule-2-Ezrin-Akt pathway in rheumatoid arthritis.
Singh K, Colmegna I, He X, Weyand CM, Goronzy JJ.J Immunol. 2008 Feb 1;180(3):1971-8.
- 2.
- Dose-response transition from cell cycle arrest to apoptosis with selective degradation of Mdm2 and p21WAF1/CIP1 in response to the novel anticancer agent, aminoflavone (NSC 686,288).
Meng LH, Kohn KW, Pommier Y.Oncogene. 2007 Jul 19;26(33):4806-16. Epub 2007 Feb 12.
- 3.
- A negative feedback signaling network underlies oncogene-induced senescence.
Courtois-Cox S, Genther Williams SM, Reczek EE, Johnson BW, McGillicuddy LT, Johannessen CM, Hollstein PE, MacCollin M, Cichowski K.Cancer Cell. 2006 Dec;10(6):459-72.
- Entrez GeneID:
- 4193
- Protein Accession#:
- NP_002383;Q00987
- Gene Name:
- MDM2
- Gene Alias:
- HDMX,MGC71221,hdm2
- Gene Description:
- Mdm2 p53 binding protein homolog (mouse)
- Omim ID:
- 164785
- Gene Ontology:
- Hyperlink
- Gene Summary:
- This gene is a target gene of the transcription factor tumor protein p53. The encoded protein is a nuclear phosphoprotein that binds and inhibits transactivation by tumor protein p53, as part of an autoregulatory negative feedback loop. Overexpression of this gene can result in excessive inactivation of tumor protein p53, diminishing its tumor suppressor function. This protein has E3 ubiquitin ligase activity, which targets tumor protein p53 for proteasomal degradation. This protein also affects the cell cycle, apoptosis, and tumorigenesis through interactions with other proteins, including retinoblastoma 1 and ribosomal protein L5. More than 40 different alternatively spliced transcript variants have been isolated from both tumor and normal tissues. [provided by RefSeq
- Other Designations:
- Mdm2, transformed 3T3 cell double minute 2, p53 binding protein,double minute 2, human homolog of; p53-binding protein,mouse double minute 2 homolog,p53-binding protein MDM2,ubiquitin-protein ligase E3 Mdm2
- Related Disease
- Abortion, Missed
- Abortion, Spontaneous
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- Acute Disease
- Adenocarcinoma
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- Carcinoma, Non-Small-Cell Lung