Phospho-CEBP beta (Thr235),磷酸化转录调节因子CEBP β抗体

产品编号HZ-3063R
英文名称Phospho-CEBP beta (Thr235)
中文名称磷酸化转录调节因子CEBP β抗体
别 名P-CEBP beta (Thr235); CEBP-beta; CLEBP beta; CCAAT Enhancer Binding Protein beta; AGP/EBP; C EBP beta; C/EBP related protein 2; CEBPB; CRP2; IL 6DBP; IL6DBP; Interleukin 6 dependent binding protein; LAP; Liver enriched transcriptional activator; NF IL6; NFIL6; Nuclear factor NF IL6; SF B; SFB; Silencer factor B; TCF5; Transcription factor 5).
说 明 书0.1ml
产品类型磷酸化抗体
研究领域肿瘤 免疫学 信号转导 细胞凋亡 转录调节因子 激酶和磷酸酶
抗体来源Rabbit
克隆类型Polyclonal
交叉反应Human, Mouse, Rat, Dog, Pig, Cow, Rabbit,
Phospho-CEBP beta (Thr235),磷酸化转录调节因子CEBP β抗体产品应用WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量38kDa
细胞定位细胞核
性 状Lyophilized or Liquid
浓 度1mg/1ml
免 疫 原KLH conjugated Synthesised phosphopeptide derived from human CEBP beta around the phosphorylation site of Thr235
亚 型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
Phospho-CEBP beta (Thr235),磷酸化转录调节因子CEBP β抗体PubMedPubMed
产品介绍background:
The protein encoded by this intronless gene is a bZIP transcription factor which can bind as a homodimer to certain DNA regulatory regions. It can also form heterodimers with the related proteins CEBP alpha, CEBP delta, and CEBP gamma. The encoded protein is important in the regulation of genes involved in immune and inflammatory responses and has been shown to bind to the IL1 response element in the IL6 gene, as well as to regulatory regions of several acute-phase and cytokine genes. In addition, the encoded protein can bind the promoter and upstream element and stimulate the expression of the collagen type I gene.

Function:
Important transcriptional activator in the regulation of genes involved in immune and inflammatory responses. Specifically binds to an IL-1 response element in the IL-6 gene. NF-IL6 also binds to regulatory regions of several acute-phase and cytokines genes. It probably plays a role in the regulation of acute-phase reaction, inflammation and hemopoiesis. The consensus recognition site is 5'-T[TG]NNGNAA[TG]-3'. Functions in brown adipose tissue (BAT) differentiation.

Subunit:
Binds DNA as a dimer and can form stable heterodimers with C/EBP alpha and gamma. Interacts with TRIM28 and PTGES2. Interacts with PRDM16. Interacts with CCDC85B. Forms a complex with THOC5 (By similarity). Interacts with ZNF638; this interaction increases transcriptional activation (By similarity).

Phospho-CEBP beta (Thr235),磷酸化转录调节因子CEBP β抗体Subcellular Location:
Nucleus.

Tissue Specificity:
Expressed at low levels in the lung, kidney and spleen.

Similarity:
Belongs to the bZIP family. C/EBP subfamily.
Contains 1 bZIP domain.

Gene ID:
1051

Database links:
Entrez Gene: 1051 Human
Entrez Gene: 12608 Mouse
Entrez Gene: 24253 Rat
Omim: 189965 Human
SwissProt: P17676 Human
SwissProt: P28033 Mouse
SwissProt: P21272 Rat
Unigene: 517106 Human
Unigene: 719041 Human
Unigene: 720603 Human
Unigene: 439656 Mouse
Unigene: 6479 Rat

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.