RB1 (phospho S780) Peptide
产品名称： RB1 (phospho S780) Peptide
英文名称： RB1 (phospho S780) Peptide
产品编号： P1403
产品价格： 0
产品产地： 台湾
品牌商标： Abnova
更新时间： null
使用范围： null
亚诺法生技股份有限公司（Abnova)
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- Specification
- Product Description:
- Rabbit polyclonal antibody raised against synthetic phosphopeptide of RB1.
- Immunogen:
- Synthetic phosphopeptide (conjugated with KLH) corresponding to residues surrounding S780 of human RB1.
- Host:
- Rabbit
- Reactivity:
- Human
- Form:
- Liquid
- Purification:
- Protein G purification
- Storage Buffer:
- In PBS (0.09% sodium azide)
- Storage Instruction:
- Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.
- Recommend Usage:
- ELISA (1:1000)
Immunohistochemistry (1:50-100)
Dot Blot (1:500)
The optimal working dilution should be determined by the end user.
- Note:
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Publication Reference
- 1.
- Retinoblastoma protein is required for efficient colorectal carcinoma cell apoptosis by histone deacetylase inhibitors in the absence of p21Waf.
Wagner S, Roemer K.Biochem Pharmacol. 2005 Apr 1;69(7):1059-67.
- 2.
- Overexpression and hyperphosphorylation of retinoblastoma protein in the progression of malignant melanoma.
Roesch A, Becker B, Meyer S, Hafner C, Wild PJ, Landthaler M, Vogt T.Mod Pathol. 2005 Apr;18(4):565-72.
- 3.
- Loss of Rb-E2F repression results in caspase-8-mediated apoptosis through inactivation of focal adhesion kinase.
Lieman JH, Worley LA, Harbour JW.J Biol Chem. 2005 Mar 18;280(11):10484-90. Epub 2005 Jan 7.
- Applications
- Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
- Formalin-fixed and paraffin-embedded human cancer tissue reacted with RB1 (phospho S780) polyclonal antibody (Cat # PAB0598) which was peroxidase-conjugated to the secondary antibody followed by AEC staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. BC = breast carcinoma.
- Entrez GeneID:
- 5925
- Protein Accession#:
- NP_000312;P06400
- Gene Name:
- RB1
- Gene Alias:
- OSRC,RB,p105-Rb,pRb,pp110
- Gene Description:
- retinoblastoma 1
- Gene Ontology:
- Hyperlink
- Gene Summary:
- The protein encoded by this gene is a negative regulator of the cell cycle and was the first tumor suppressor gene found. The encoded protein also stabilizes constitutive heterochromatin to maintain the overall chromatin structure. The active, hypophosphorylated form of the protein binds transcription factor E2F1. Defects in this gene are a cause of childhood cancer retinoblastoma (RB), bladder cancer, and osteogenic sarcoma. [provided by RefSeq
- Other Designations:
- OTTHUMP00000018397,retinoblastoma suspectibility protein,retinoblastoma-associated protein
- Related Disease
- Adenocarcinoma
- Breast cancer
- Breast Neoplasms
- Carcinoma
- Carcinoma, Hepatocellular
- Carcinoma, Squamous Cell
- Chromosomal Instability
- Chromosome Aberrations
- Chromosome Deletion
- Colorectal Neoplasms
- Cystadenocarcinoma, Serous
- Disease Progression
- Esophageal Neoplasms
- Genetic Predisposition to Disease
- Head and Neck Neoplasms
- Liver Neoplasms
- Lung Neoplasms
- Lymphoma, Mantle-Cell
- Neoplasm Invasiveness