HCN3,钾/钠超极化激活环核苷酸门控通道蛋白3抗体'

产品编号HZ-9856R
英文名称HCN3
中文名称钾/钠超极化激活环核苷酸门控通道蛋白3抗体
别 名Hcn3; HCN3_HUMAN; hyperpolarization activated cyclic nucleotide-gated potassium channel 3; KIAA1535; potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 3.
说 明 书0.1ml 0.2ml
研究领域心血管 神经生物学 信号转导 通道蛋白
抗体来源Rabbit
克隆类型Polyclonal
交叉反应 Human, Mouse, Rat, Cow, Horse, Rabbit,
HCN3,钾/钠超极化激活环核苷酸门控通道蛋白3抗体产品应用WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:50-200 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量86kDa
细胞定位细胞膜
性 状Lyophilized or Liquid
浓 度1mg/1ml
免 疫 原KLH conjugated synthetic peptide derived from human HCN3
亚 型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
HCN3,钾/钠超极化激活环核苷酸门控通道蛋白3抗体PubMedPubMed
产品介绍background:
Hyperpolarization-activated, cyclic nucleotide-binding channels (HCN) are voltage-gated cation channels that are activated by direct binding of intracellular cyclic nucleotides. The HCN family consists of four members (HCN1-4), each with a core transmembrane segment domain and a C-terminal 120 amino-acid cyclic nucleotide-binding domain motif. HCN channels are expressed in the brain, heart, thalamus and testis. The pacemaker properties of HCN channels contribute to spontaneous rhythmic activity in the brain and heart. HCN3 contains a segment characterized by a series of positively charged amino acids at every third position. This region designated S4 is likely to be the voltage sensor of the protein. In the brain, HCN3 and HCN4 exhibit subcortical distribution mainly concentrated in the hypothalamus and thalamus, respectively.

Function:
Putative hyperpolarization-activated ion channel exhibiting weak selectivity for potassium over sodium ions (By similarity).

Subunit:
The potassium channel is probably composed of a homo- or heterotetrameric complex of pore-forming subunits.

Subcellular Location:
Membrane; Multi-pass membrane protein.

Similarity:
Belongs to the potassium channel HCN family.
Contains 1 cyclic nucleotide-binding domain.

Database links:
Entrez Gene: 57657 Human
Entrez Gene: 15168 Mouse
Entrez Gene: 114245 Rat
Omim: 609973 Human
SwissProt: Q9P1Z3 Human
SwissProt: O88705 Mouse
SwissProt: Q9JKA8 Rat
Unigene: 706960 Human
Unigene: 389461 Mouse
Unigene: 48801 Rat

HCN3,钾/钠超极化激活环核苷酸门控通道蛋白3抗体Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.