FITC标记的鸡新城疫血凝素－神经氨酸酶抗体
产品名称： FITC标记的鸡新城疫血凝素－神经氨酸酶抗体
英文名称： Anti-NDV HN protein/FITC
产品编号： HZ-4529R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： IF=1:50-200
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Rabbit Anti-NDV HN protein/FITC Conjugated antibody
FITC标记的鸡新城疫血凝素－神经氨酸酶抗体
| 英文名称 | Anti-NDV HN protein/FITC |
| 中文名称 | FITC标记的鸡新城疫血凝素－神经氨酸酶抗体 |
| 别 名 | hemagglutinin-neuraminidase protein; newcastle disease virus(NDV); HN protein; hemagglutinin-neuraminidase protein [Newcastle disease virus]; HN_NDVB; Newcastle disease virus HN protein; Newcastle disease virus hemagglutinin neuraminidase protein. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 免疫学 细菌及病毒 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | NDV |
| 产品应用 | IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 63kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from NDV HN protein |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: The entry of Newcastle disease virus (NDV), a prototype paramyxovirus, is directed by two virion glycoproteins, the hemagglutinin-neuraminidase (HN) protein and the fusion (F) protein . HN protein, the virus attachment protein, binds to sialic acid-containing receptors, and F protein mediates membrane fusion. In contrast to many viral fusion proteins, paramyxovirus F proteins do not require the acid pH of endosomes to activate fusion activity. As a consequence, infected cells expressing both attachment proteins and F proteins can fuse with adjacent cells to form multinuclear cells, or syncytia, a process that is assumed to mimic virus-cell fusion . Function: Attaches the virus to sialic acid-containing cell receptors and thereby initiating infection. Binding of HN protein to the receptor induces a conformational change that allows the F protein to trigger virion/cell membranes fusion (By similarity). Neuraminidase activity ensures the efficient spread of the virus by dissociating the mature virions from the neuraminic acid containing glycoproteins (By similarity). Subcellular Location: Virion membrane; Single-pass type II membrane protein (Potential). Host cell membrane; Single-pass type II membrane protein (Potential). Similarity: Belongs to the paramyxoviruses hemagglutinin-neuraminidase family. Database links: Entrez Gene: 912270 NDVSwissProt: P32884 NDV Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
纽卡斯尔病病毒（NDV）是一种副粘病毒原型，由两个病毒蛋白糖蛋白、血凝素神经氨酸酶（HN）蛋白和融合蛋白（F）组成。HN蛋白是病毒附着蛋白，结合唾液酸受体，F蛋白介导膜融合。与许多病毒融合蛋白相反，副粘病毒F蛋白不需要内涵体的酸性pH来激活融合活性。因此，表达附着蛋白和F蛋白的感染细胞可以与相邻细胞融合形成多核细胞，或合胞体，这是假定模拟病毒细胞融合的过程。