重组人Nanog基因（Human Nanog）

Prolactin is a lactogenic hormone secreted by the adenohypophysis .Besides its major action on lactation, in some species prolactin exerts effects on reproduction, maternal behavior, fat metabolism, immunomodulation and osmoregulation.Prolactin has been shown also to have cytokine-like activities and to have important immunoregulatory activities. It contributes to the development of lymphoid tissues and the maintenance of physiological immune function and also modulates a variety of T-cell immune responses. Prolactin has been reported to activate cellular proliferation in nonreproductive tissue, such as liver, spleen, and thymus. It induces significant proliferation in aortic smooth muscle cells and also enhances proliferation of these cells induced by PDGF . Prolactin also appears to be directly mitogenic for pancreatic beta cells. Prolactin is also mitogenic for cultured astrocytes. 

重组人Nanog基因（Human Nanog）

结缔组织生长因子（connective tissue growth factor，CTGF）是一种新发现可刺激成纤维细胞增殖和胶原沉积生长因子，是高度保守CCN（CTGF、Cef10/cyr61和Nov缩写）多肽家族中成员。CTGF蛋白为肝素结合型，含349个氨基酸，富含半胱氨酸，其分子量约为36~38kD，可由成纤维细胞、平滑肌细胞和内皮细胞合成分泌。成年哺乳动物心、脑、肾、肺、肝胎盘中均有表达。人类CTGF基因定位于染色体6q23。1，包括5个外显子，4个内含子。起始位点为ATG，其3′端包含三个ATTTA位点。CTGF蛋白38个保守半胱氨酸残基分成两个节段，其中22个在N末端区，16个在C末端区，4个主要蛋白结构区为胰岛素样生长因子结合蛋白区、von Wille-brand因子C型重复、血小板反应蛋白（throm bospondin）I型重复以及生长因子半胱氨酸群，这些区域都由独立外显因子编码。CTGF广泛表达于人类多种组织器官中，在病理情况下，其过度表达与某些增生性或纤维化疾病发生发展密切相关，如硬皮病、肾纤维化、肝硬化、肺纤维化、动脉粥样硬化等。

重组人Nanog基因（Human Nanog）