DSU,视杆细胞相关蛋白MREG抗体

产品编号HZ-14433R
英文名称DSU
中文名称视杆细胞相关蛋白MREG抗体
别 名Dilute suppressor; Dilute suppressor protein homolog; DSU; FLJ10116; MREG_HUMAN; Melanoregulin; MGC90296; MREG; OTTHUMP00000206794; OTTHUMP00000206795; OTTHUMP00000206796; WDT 2; WDT2; Whn dependent transcript 2.
说 明 书0.1ml 0.2ml
研究领域细胞生物 免疫学 神经生物学
抗体来源Rabbit
克隆类型Polyclonal
交叉反应Human, Mouse, Rat, Dog, Pig, Cow, Horse,
DSU,视杆细胞相关蛋白MREG抗体产品应用WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量25kDa
性 状Lyophilized or Liquid
浓 度1mg/1ml
免 疫 原KLH conjugated synthetic peptide derived from human DSU
亚 型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
DSU,视杆细胞相关蛋白MREG抗体PubMedPubMed
产品介绍background:
The photoreceptor rod cell that is responsible for vision under conditions of low light consists of stacked arrays of disk membranes that make up its outer segment portion. Regulated by complex biochemical mechanisms, the rod outer segment is under constant renewal as new disks form at the base. MREG (melanoregulin), also known as DSU (dilute suppressor protein homolog) or WDT2, is thought to play a role in membrane fusion and in regulating the biogenesis of disk membranes of photoreceptor rods. MREG interacts with RDS (also known as Peripherin-2), a photoreceptor specific tetraspanin protein that is required to maintain normal cell structure during the renewal process of membrane fusion. MREG is 214 amino acids in length, is expressed in photoreceptor cells and and is expressed as two isoforms due to alternative splicing.

Function:
DSU (Dilute suppressor) is also known as Melanoregulin. It has a role in the incorporation of pigments into hair. It is involved in organelle biogenesis and may function in membrane fusion. It may also regulate the biogenesis of disk membranes, specialized organelles of photoreceptor rod cells.

Subcellular Location:
Apical cell membrane; Peripheral membrane protein. Note: Localizes to the inner segment and basal outer segment of rods in the retina.

Tissue Specificity:
Expressed in photoreceptor cells (at protein level).

Similarity:
Belongs to the melanoregulin family.

Gene ID:
55686

DSU,视杆细胞相关蛋白MREG抗体Database links:
Entrez Gene: 55686 Human
Entrez Gene: 381269 Mouse
Omim: 609207 Human
SwissProt: Q8N565 Human
SwissProt: Q6NVG5 Mouse

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.