FITC标记的软骨中间层蛋白CILP2抗体
产品名称： FITC标记的软骨中间层蛋白CILP2抗体
英文名称： Anti-CILP2/FITC
产品编号： HZ-13955R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： ICC=1:50-200 IF=1:50-200
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Rabbit Anti-CILP2/FITC Conjugated antibody
FITC标记的软骨中间层蛋白CILP2抗体
| 英文名称 | Anti-CILP2/FITC |
| 中文名称 | FITC标记的软骨中间层蛋白CILP2抗体 |
| 别 名 | Cartilage intermediate layer protein 2 C2; CILP-2; CILP2; CILP2_HUMAN; MGC45771. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 细胞生物 免疫学 信号转导 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Pig, Cow, Horse, Rabbit, Sheep, |
| 产品应用 | ICC=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 126kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human CILP2 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: Cartilage intermediate layer protein (CILP), an extracellular matrix protein, shows abundant expression in cartilagenous tissues. CILP is expressed as two isoforms, CILP and CILP-2, which are differentially expressed by chondrocytes and induced by TGF∫1. This induction is mediated by Smad3 through direct interactions with cis-elements in the CILP promoter region. TGF∫ also induces elevated chondrocyte extracellular inorganic pyrophosphate (PPi), which promotes the deposition of calcium pyrophosphate dihydrate crystals. The CILP isoforms have been implicated in common musculoskeletal disorders, including osteoarthritis, rheumatoid arthritis and lumbar disc disease. Function: May play a role in cartilage scaffolding. Subcellular Location: Secreted > extracellular space > extracellular matrix. Tissue Specificity: Expressed in articular chondrocytes but not in knee meniscal cartilage cells. Post-translational modifications: May be cleaved into 2 chains possibly by a furin-like protease upon or preceding secretion. Similarity: Contains 1 Ig-like C2-type (immunoglobulin-like) domain. Contains 1 TSP type-1 domain. Database links: Entrez Gene: 148113 Human Omim: 612419 Human SwissProt: Q8IUL8 Human Unigene: 279574 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
软骨中间层蛋白（CILP）是一种细胞外基质蛋白，在软骨组织中具有丰富的表达。CILP表现为两种异构体、CILP和CILP-2，它们由软骨细胞表达差异，TGFβ1诱导。这种诱导通过SMAD3介导，通过与CILP启动子区域中的顺式元件的直接相互作用。TGF_还可诱导软骨细胞胞外无机焦磷酸盐（PPi）升高，促进二水焦磷酸钙晶体的沉积。CILP亚型与常见的肌肉骨骼疾病有关，包括骨关节炎、类风湿性关节炎和腰椎间盘疾病。