FGFR1 polyclonal antibody
产品名称： FGFR1 polyclonal antibody
英文名称： FGFR1 polyclonal antibody
产品编号： PAB2087
产品价格： null
产品产地： 台湾
品牌商标： Abnova
更新时间： null
使用范围：
亚诺法生技股份有限公司（Abnova)
- 联系人 :
- 地址 : 台湾台北市内湖区洲子街 108 号 9 楼
- 邮编 : 11493
- 所在区域 : 台湾
- 电话 : +886-920**1152 点击查看
- 传真 : 点击查看
- 邮箱 : sales@abnova.com.tw
- Specification
- Product Description:
- Rabbit polyclonal antibody raised against synthetic peptide of FGFR1.
- Immunogen:
- A synthetic peptide (conjugated with KLH) corresponding to residues surrounding Y653 of human FGFR1.
- Host:
- Rabbit
- Reactivity:
- Human
- Form:
- Liquid
- Purification:
- Protein A purification
- Storage Buffer:
- In PBS (0.09% sodium azide)
- Storage Instruction:
- Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.
- Recommend Usage:
- ELISA (1:1000)
Western Blot (1:50-100)
The optimal working dilution should be determined by the end user.
- Note:
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Publication Reference
- 1.
- Expression patterns of epidermal growth factor receptor and fibroblast growth factor receptor 1 mRNA in fetal human brain.
Fu L, Abu-Khalil A, Morrison RS, Geschwind DH, Kornblum HI.J Comp Neurol. 2003 Jul 21;462(2):265-73.
- 2.
- Differential tyrosine phosphorylation of fibroblast growth factor (FGF) receptor-1 and receptor proximal signal transduction in response to FGF-2 and heparin.
Lundin L, Ronnstrand L, Cross M, Hellberg C, Lindahl U, Claesson-Welsh L.Exp Cell Res. 2003 Jul 1;287(1):190-8.
- 3.
- Alternatively spliced FGFR-1 isoform signaling differentially modulates endothelial cell responses to peroxynitrite.
Jiao J, Greendorfer JS, Zhang P, Zinn KR, Diglio CA, Thompson JA.Arch Biochem Biophys. 2003 Feb 15;410(2):187-200.
- Entrez GeneID:
- 2260
- Protein Accession#:
- NP_000595;P11362
- Gene Name:
- FGFR1
- Gene Alias:
- BFGFR,CD331,CEK,FGFBR,FLG,FLJ99988,FLT2,HBGFR,KAL2,N-SAM
- Gene Description:
- fibroblast growth factor receptor 1
- Gene Ontology:
- Hyperlink
- Gene Summary:
- The protein encoded by this gene is a member of the fibroblast growth factor receptor (FGFR) family, where amino acid sequence is highly conserved between members and throughout evolution. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein consists of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. This particular family member binds both acidic and basic fibroblast growth factors and is involved in limb induction. Mutations in this gene have been associated with Pfeiffer syndrome, Jackson-Weiss syndrome, Antley-Bixler syndrome, osteoglophonic dysplasia, and autosomal dominant Kallmann syndrome 2. Chromosomal aberrations involving this gene are associated with stem cell myeloproliferative disorder and stem cell leukemia lymphoma syndrome. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized. [provided by RefSeq
- Other Designations:
- FMS-like tyrosine kinase 2,OTTHUMP00000190874,OTTHUMP00000190878,OTTHUMP00000190879,OTTHUMP00000190881,basic fibroblast growth factor receptor 1,fms-related tyrosine kinase 2,fms-related tyrosine kinase-2,heparin-binding growth factor receptor,hydroxyaryl
- Interactome
- Related Disease
- Abnormalities, Multiple
- Acrocephalosyndactylia
- Alzheimer Disease
- Alzheimer disease
- Amenorrhea
- Anodontia
- Breast cancer
- Breast Neoplasms
- Bronchial Hyperreactivity
- Cardiovascular Diseases
- Chromosome Aberrations
- Chromosome Disorders
- Cleft Lip
- Cleft Palate
- Craniofacial Dysostosis
- Craniosynostoses
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- Fractures, Bone
- Genetic Diseases, Inborn