RAD51 polyclonal antibody
产品名称： RAD51 polyclonal antibody
英文名称： RAD51 polyclonal antibody
产品编号： PAB12308
产品价格： null
产品产地： 台湾
品牌商标： Abnova
更新时间： null
使用范围：
亚诺法生技股份有限公司（Abnova)
- 联系人 :
- 地址 : 台湾台北市内湖区洲子街 108 号 9 楼
- 邮编 : 11493
- 所在区域 : 台湾
- 电话 : +886-920**1152 点击查看
- 传真 : 点击查看
- 邮箱 : sales@abnova.com.tw
- Specification
- Product Description:
- Rabbit polyclonal antibody raised against synthetic peptide of RAD51.
- Immunogen:
- A synthetic peptide corresponding to amino acids at N-terminus of human RAD51.
- Sequence:
- QMQLEANADTSVEEESF
- Host:
- Rabbit
- Theoretical MW (kDa):
- 36.9
- Reactivity:
- Human, Mouse, Rat
- Specificity:
- Different from the related rat sequence by one amino acid.
- Form:
- Lyophilized
- Purification:
- Affinity purification
- Storage Buffer:
- Lyophilized from 0.9 mg NaCl, 0.2 mg Na2HPO4 (5 mg BSA, 0.05 mg sodium azide, 0.05 mg Thimerosal)
- Storage Instruction:
- Store at -20°C on dry atmosphere.
After reconstitution with 200 uL of deionized water and concentration will be 500 ug/mL, store at -20°C or lower.
Aliquot to avoid repeated freezing and thawing.
- Quality Control Testing:
- Antibody Reactive Against Synthetic Peptide.
- Recommend Usage:
- Western Blot (1 ug/mL)
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (1-2 ug/mL)
The optimal working dilution should be determined by the end user.
- Note:
- This product contains sodium azide and thimerosal: POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Publication Reference
- 1.
- Highlight: BRCA1 and BRCA2 proteins in breast cancer.
Daniel DC.Microsc Res Tech. 2002 Oct 1;59(1):68-83.
- 2.
- Identification of Rad51 alteration in patients with bilateral breast cancer.
Kato M, Yano K, Matsuo F, Saito H, Katagiri T, Kurumizaka H, Yoshimoto M, Kasumi F, Akiyama F, Sakamoto G, Nagawa H, Nakamura Y, Miki Y.J Hum Genet. 2000;45(3):133-7.
- Application Image
- Western Blot
- Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
- enlarge
- Entrez GeneID:
- 5888
- Gene Name:
- RAD51
- Gene Alias:
- BRCC5,HRAD51,HsRad51,HsT16930,RAD51A,RECA
- Gene Description:
- RAD51 homolog (RecA homolog, E. coli) (S. cerevisiae)
- Gene Ontology:
- Hyperlink
- Gene Summary:
- The protein encoded by this gene is a member of the RAD51 protein family. RAD51 family members are highly similar to bacterial RecA and Saccharomyces cerevisiae Rad51, and are known to be involved in the homologous recombination and repair of DNA. This protein can interact with the ssDNA-binding protein RPA and RAD52, and it is thought to play roles in homologous pairing and strand transfer of DNA. This protein is also found to interact with BRCA1 and BRCA2, which may be important for the cellular response to DNA damage. BRCA2 is shown to regulate both the intracellular localization and DNA-binding ability of this protein. Loss of these controls following BRCA2 inactivation may be a key event leading to genomic instability and tumorigenesis. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq
- Other Designations:
- BRCA1/BRCA2-containing complex, subunit 5,DNA repair protein RAD51 homolog 1,RAD51 homolog protein,RAD51, S.cerevisiae, homolog of, A,RecA, E. coli, homolog of,RecA-like protein,recombination protein A
- Related Disease
- Acute Disease
- Adenocarcinoma
- Ataxia telangiectasia
- Brain Neoplasms
- Breast cancer
- Breast Neoplasms
- Carcinoma
- Carcinoma, Ductal
- Carcinoma, Ductal, Breast
- Carcinoma, Intraductal, Noninfiltrating
- Carcinoma, Lobular
- Carcinoma, Non-Small-Cell Lung
- Carcinoma, Papillary
- Carcinoma, Squamous Cell
- Carcinoma, Transitional Cell
- Chromosome Aberrations
- Colorectal Neoplasms
- DNA Damage
- DNA Repair-Deficiency Disorders