FITC标记的TRIOBP蛋白抗体
产品名称： FITC标记的TRIOBP蛋白抗体
英文名称： Anti-TRIOBP/FITC
产品编号： HZ-17152R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： ICC=1:50-200 IF=1:50-200
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Rabbit Anti-TRIOBP/FITC Conjugated antibody
FITC标记的TRIOBP蛋白抗体
| 英文名称 | Anti-TRIOBP/FITC |
| 中文名称 | FITC标记的TRIOBP蛋白抗体 |
| 别 名 | DFNB28; KIAA1662; Protein TARA; TARA; TARA_HUMAN; Tara like protein; TRIO and F actin binding protein; Trio and filamentous actin binding protein; Trio associated repeat on actin. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 细胞生物 信号转导 结合蛋白 细胞骨架 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit, Sheep, |
| 产品应用 | ICC=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 261kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human TRIOBP |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: This gene encodes a protein with an N-terminal pleckstrin homology domain and a C-terminal coiled-coil region. The protein interacts with trio, which is involved with neural tissue development and controlling actin cytoskeleton organization, cell motility and cell growth. The protein also associates with F-actin and stabilizes F-actin structures. Mutations in this gene have been associated with a form of autosomal recessive nonsyndromic deafness. Multiple alternatively spliced transcript variants that would encode different isoforms have been found for this gene, however some transcripts may be subject to nonsense-mediated decay (NMD). [provided by RefSeq, Nov 2008] Function: TRIOBP is a protein that interacts with trio, which is involved with neural tissue development and controlling actin cytoskeleton organization, cell motility and cell growth. This trio binding protein also associates with F actin and stabilizes F actin structures. Subunit: Binds to TRIO and F-actin. May also interact with myosin II. Interacts with HECTD3. Subcellular Location: Nucleus. Cytoplasm; cytoskeleton. Note: Localized to F-actin in a periodic pattern. Tissue Specificity: Widely expressed. Highly expressed in heart and placenta. Isoform 3 is expressed in fetal brain, retina and cochlea but is not detectable in the other tissues. Post-translational modifications: Ubiquitinated by HECTD3, leading to its degradation by the proteasome. Isoform 1: Phosphorylation at Thr-457 by PLK1 ensures mitotic progression and is essential for accurate chromosome segregation. DISEASE: Deafness, autosomal recessive, 28 (DFNB28) [MIM:609823]: A form of non-syndromic sensorineural hearing loss. Sensorineural deafness results from damage to the neural receptors of the inner ear, the nerve pathways to the brain, or the area of the brain that receives sound information. Note=The disease is caused by mutations affecting the gene represented in this entry. Similarity: Contains 1 PH domain. Database links: Entrez Gene: 11078 Human Entrez Gene: 511680 Cow Entrez Gene: 110253 Mouse Entrez Gene: 362956 Rat Omim: 609761 Human SwissProt: Q9H2D6 Human SwissProt: Q99KW3 Mouse Unigene: 533030 Human Unigene: 123714 Mouse Unigene: 119950 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
该基因编码具有N-末端Prkkistin同源结构域和C-末端卷曲螺旋区的蛋白质。该蛋白与三重体相互作用，三重体参与神经组织发育，控制肌动蛋白细胞骨架组织、细胞运动和细胞生长。该蛋白还与F-肌动蛋白结合并稳定F-肌动蛋白结构。该基因的突变与常染色体隐性遗传非综合征性耳聋有关。已经发现该基因的多个可替代剪接的转录体变体，它们可以编码不同的异构体，然而，一些转录体可能遭受无意义介导的衰变(NMD)。[ RefSeq，2008月11日]