PARK2 (N-term) Peptide
产品名称： PARK2 (N-term) Peptide
英文名称： PARK2 (N-term) Peptide
产品编号： P2043
产品价格： 0
产品产地： 台湾
品牌商标： Abnova
更新时间： null
使用范围： null
亚诺法生技股份有限公司（Abnova)
- 联系人 :
- 地址 : 台湾台北市内湖区洲子街 108 号 9 楼
- 邮编 : 11493
- 所在区域 : 台湾
- 电话 : +886-920**1152 点击查看
- 传真 : 点击查看
- 邮箱 : sales@abnova.com.tw
- Specification
- Product Description:
- Rabbit polyclonal antibody raised against synthetic peptide of PARK2.
- Immunogen:
- A synthetic peptide (conjugated with KLH) corresponding to N-terminus of human PARK2.
- Host:
- Rabbit
- Reactivity:
- Human
- Form:
- Liquid
- Purification:
- Ammonium sulfate precipitation
- Storage Buffer:
- In PBS (0.09% sodium azide)
- Storage Instruction:
- Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.
- Recommend Usage:
- ELISA (1:1000)
Western Blot (1:100-500)
The optimal working dilution should be determined by the end user.
- Note:
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Publication Reference
- 1.
- Rapid eye movement sleep behavior disorder in parkinsonism with parkin mutations.
Kumru H, Santamaria J, Tolosa E, Valldeoriola F, Munoz E, Marti MJ, Iranzo A.Ann Neurol. 2004 Oct;56(4):599-603.
- 2.
- Mutational analysis of parkin gene by denaturing high-performance liquid chromatography (DHPLC) in essential tremor.
Pigullo S, De Luca A, Barone P, Marchese R, Bellone E, Colosimo A, Scaglione C, Martinelli P, Di Maria E, Pizzuti A, Abbruzzese G, Dallapiccola B, Ajmar F, Mandich P.Parkinsonism Relat Disord. 2004 Aug;10(6):357-62.
- 3.
- Nitrosative stress linked to sporadic Parkinson's disease: S-nitrosylation of parkin regulates its E3 ubiquitin ligase activity.
Yao D, Gu Z, Nakamura T, Shi ZQ, Ma Y, Gaston B, Palmer LA, Rockenstein EM, Zhang Z, Masliah E, Uehara T, Lipton SA.Proc Natl Acad Sci U S A. 2004 Jul 20;101(29):10810-4. Epub 2004 Jul 13.
- Entrez GeneID:
- 5071
- Protein Accession#:
- NP_004553.1
- Gene Name:
- PARK2
- Gene Alias:
- AR-JP,LPRS2,PDJ,PRKN
- Gene Description:
- Parkinson disease (autosomal recessive, juvenile) 2, parkin
- Gene Ontology:
- Hyperlink
- Gene Summary:
- The precise function of this gene is unknown; however, the encoded protein is a component of a multiprotein E3 ubiquitin ligase complex that mediates the targeting of substrate proteins for proteasomal degradation. Mutations in this gene are known to cause Parkinson disease and autosomal recessive juvenile Parkinson disease. Alternative splicing of this gene produces multiple transcript variants encoding distinct isoforms. Additional splice variants of this gene have been described but currently lack transcript support. [provided by RefSeq
- Other Designations:
- E3 ubiquitin ligase,OTTHUMP00000017565,OTTHUMP00000017566,OTTHUMP00000017567,parkin,parkin 2
- Interactome
- Gene Pathway
- Related Disease
- Alzheimer disease
- Cardiovascular Diseases
- Choice Behavior
- Cognition Disorders
- Diabetes Mellitus, Type 2
- Diabetic Nephropathies
- Disease Progression
- Disease Susceptibility
- Dystonic Disorders
- Edema
- Essential Tremor
- Essential tremor
- Genetic Predisposition to Disease
- Leprosy
- Movement Disorders
- Nerve Degeneration
- Neuropsychological Tests
- Paratyphoid Fever
- Parkinson Disease