蛋白激酶样内质网激酶抗体
产品名称: 蛋白激酶样内质网激酶抗体
英文名称: PERK
产品编号: bs-2469R
产品价格: null
产品产地: 北京
品牌商标: BIOSS
更新时间: 2025-01-07T10:18:04
使用范围: WB=1:100-500,ELISA=1:500-1000,IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500,
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The protein encoded by this gene phosphorylates the alpha subunit of eukaryotic translation-initiation factor 2 (EIF2), leading to its inactivation, and thus to a rapid reduction of translational initiation and repression of global protein synthesis. It is a type I membrane protein located in the endoplasmic reticulum (ER), where it is induced by ER stress caused by malfolded proteins. Mutations in this gene are associated with Wolcott-Rallison syndrome. [provided by RefSeq, Jan 2010]