FITC标记的固生蛋白3抗体
产品名称： FITC标记的固生蛋白3抗体
英文名称： Anti-ODZ3/FITC
产品编号： HZ-
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： ICC=1:50-200 IF=1:50-200
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Rabbit Anti-ODZ3/FITC Conjugated antibody
FITC标记的固生蛋白3抗体
| 产品编号 | bs-9061R-FITC |
| 英文名称 | Anti-ODZ3/FITC |
| 中文名称 | FITC标记的固生蛋白3抗体 |
| 别 名 | ODZ3 like protein; Protein Odd Oz ten m homolog 3; Ten 3; Ten M3; Tenascin M3; Teneurin 3; Teneurin3; TNM3; FLJ10474; FLJ10886; KIAA1455; odd Oz Ten m homolog 3; odz odd Oz ten m homolog 3 (Drosophila); odz odd Oz ten m homolog 3; TEN3_HUMAN. a |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 肿瘤 细胞生物 免疫学 神经生物学 信号转导 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Sheep, |
| 产品应用 | ICC=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 301kDa |
| 细胞定位 | 细胞膜 |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human ODZ3/Teneurin 3 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: Teneurin-3, also known as Ten-3, TNM3 or ODZ3, is a 2,699 amino acid single-pass type II membrane protein that contains 25 YD repeats, 8 EGF-like domains, 5 NHL repeats and one teneurin N-terminal domain. Localized to the membrane and expressed in brain, testis and ovary, Teneurin-3 exists as a disulfide-liked homodimer that is thought to function as a cellular signal transducer. Additionally, Teneurin-3 may participate in eye-specific patterning in the visual pathway and is required for aligned binocular vision. The gene encoding Teneurin-3 maps to chromosome 4. Representing approximately 6% of the human genome, chromosome 4 contains nearly 900 genes, one of which is the Huntingtin gene, which is found to encode an expanded glutamine tract in cases of Huntington's disease. FGFR-3 is also encoded on chromosome 4 and has been associated with thanatophoric dwarfism, achondroplasia, Muenke syndrome and bladder cancer. Chromosome 4 is also tied to Ellis-van Creveld syndrome, methylmalonic acidemia and polycystic kidney disease. Function: Involved in neural development, regulating the establishment of proper connectivity within the nervous system. Promotes axon guidance and homophilic cell adhesion. Plays a role in the development of the visual pathway; regulates the formation in ipsilateral retinal mapping to both the dorsal lateral geniculate nucleus (dLGN) and the superior colliculus (SC). May be involved in the differentiation of the fibroblast-like cells in the superficial layer of mandibular condylar cartilage into chondrocytes. May function as a cellular signal transducer (By similarity). Subunit: Homodimer; disulfide-linked (Probable). Subcellular Location: Membrane; Single-pass type II membrane protein.Cell projection, axon (By similarity). Tissue Specificity: Expressed in adult and fetal brain, slightly lower levels in testis and ovary, and intermediate levels in all other peripheral tissues examined. Not expressed in spleen or liver. Expression was high in brain, with highest levels in amygdala and caudate nucleus, followed by thalamus and subthalamic nucleus. DISEASE: Note=Defects in TENM3 are a cause of microphthalmia, isolated, with coloboma (MCOPCB). Microphthalmia is a disorder of eye formation, ranging from small size of a single eye to complete bilateral absence of ocular tissues. Ocular abnormalities like opacities of the cornea and lens, scaring of the retina and choroid, cataract and other abnormalities like cataract may also be present. Ocular colobomas are a set of malformations resulting from abnormal morphogenesis of the optic cup and stalk, and the fusion of the fetal fissure (optic fissure). [SIMILARITY] Belongs to the tenascin family. Teneurin subfamily. Similarity: Contains 8 EGF-like domains. Contains 5 NHL repeats. Contains 1 teneurin N-terminal domain. Contains 23 YD repeats. Database links: Entrez Gene: 55714 Human Entrez Gene: 23965 Mouse Omim: 610083 Human SwissProt: Q9P273 Human SwissProt: Q9WTS6 Mouse Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
TUNEIN -3，也称为TY-3，TNM3或ODZ3，是一个2699氨基酸的单程II型膜蛋白，包含25个YD重复序列，8个EGF-样结构域，5个NHL重复序列和一个张力蛋白N端结构域。定位于膜并在脑、睾丸和卵巢中表达，Tyelin -3作为二硫键类似的同源二聚体存在，被认为是细胞信号转导子。此外，Tyelin -3可以参与视觉通路中的眼睛特异性图案化，并且需要对准双眼视觉。编码Tyelin -3的基因定位于第4号染色体。约占人类基因组的6%，4号染色体含有近900个基因，其中一个是亨廷顿基因，发现亨廷顿病的情况下，编码谷氨酰胺扩张道。FGFR-3也编码在4号染色体上，并与致死性侏儒症、软骨发育不全、Munkes综合征和膀胱癌有关。第4号染色体也与Ellis van Creveld综合征、甲基丙二酸血症和多囊肾病有关。