Netrin G2,轴突生长诱向因子G2/神经突起生长导向因子G2抗体

产品编号HZ-11103R
英文名称Netrin G2
中文名称轴突生长诱向因子G2/神经突起生长导向因子G2抗体
别 名Laminet 2; Laminet-2; Laminet2;Lmnt2; Lmnt 2; Lmnt-2; Netrin-G2; NetrinG2; NTNG1; NTNG 1; NTNG-1; NTNG2; NTNG 2; NTNG-2; NTNG2_HUMAN; bA479K20.1; LHLL9381.
说 明 书0.1ml 0.2ml
研究领域神经生物学 生长因子和激素 细胞膜蛋白
抗体来源Rabbit
克隆类型Polyclonal
交叉反应 Human, Mouse, Rat, Dog, Cow, Sheep,
Netrin G2,轴突生长诱向因子G2/神经突起生长导向因子G2抗体产品应用WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量56kDa
细胞定位细胞膜
性 状Lyophilized or Liquid
浓 度1mg/1ml
免 疫 原KLH conjugated synthetic peptide derived from human Netrin G2
亚 型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
Netrin G2,轴突生长诱向因子G2/神经突起生长导向因子G2抗体PubMedPubMed
产品介绍background:
Netrin proteins are a family of laminin-related secreted proteins that provide guidance signals for axonal growth and cell migration during development. Netrin-1, which is the mammalian homolog of UNC-6 from C. elegans, is largely expressed in the developing nervous system and in mesodermal tissues. Netrin-1 is expressed by the floor plate as either a cell associated protein or in a diffusible form, and it binds to several surface receptor components, including deleted in colorectal cancer (DCC) and neogenin. During embryonic development, netrin-1 diffuses through the neuronal epithelium, where it forms a chemoattractant gradient that directs axonal migration to the ventral midline of the spinal cord. Netrin-2 and the corresponding mouse homolog netrin-3 are expressed primarily in the lower two-thirds of the spinal cord, and, like netrin-1, they can either attract or repel commissural axons at a distance. Netrin signaling is dependent on the concentration of calcium outside the cell and the level of PKA activity. In axonal cells, a reduction in PKA activity converts the responsiveness of the axons to the netrin proteins, as the cells are repelled, rather than attracted, by the netrin gradient.

Function:
Promotes neurite outgrowth of both axons and dendrites.

Subunit:
Interacts with LRRC4 (By similarity).

Subcellular Location:
Cell membrane.

Post-translational modifications:
N-glycosylated (By similarity).

Netrin G2,轴突生长诱向因子G2/神经突起生长导向因子G2抗体Similarity:
Contains 3 laminin EGF-like domains.
Contains 1 laminin N-terminal domain.

Gene ID:
84628

Database links:
Entrez Gene: 84628 Human
Entrez Gene: 171171 Mouse
Entrez Gene: 311836 Rat
SwissProt: Q96CW9 Human
SwissProt: Q8R4F1 Mouse
Unigene: 163642 Human
Unigene: 442448 Mouse
Unigene: 218540 Rat

Netrin G2,轴突生长诱向因子G2/神经突起生长导向因子G2抗体Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.