Uniprot ID:Q93034
Species Reactivity:Human
Antibody type:Polyclonal Antibody
Aliases:CUL-5,Vasopressin-activated calcium-mobilizing receptor 1,VACM-1,CUL5,VACM1Raised in:Rabbit
Background\Function :Core component of multiple SCF-like ECS (Elongin-Cullin 2/5-SOCS-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. As a scaffold protein may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The functional specificity of the E3 ubiquitin-protein ligase complex depends on the variable substrate recognition component. ECS(SOCS1) seems to direct ubiquitination of JAK2. Seems to be involved in proteosomal degradation of p53/TP53 stimulated by adenovirus E1B-55 kDa protein. May form a cell surface vasopressin receptor.
Stroage Buffer:PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Purity:Antigen Affinity Purified
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