FITC标记的Smad核相互作用蛋白1抗体
产品名称： FITC标记的Smad核相互作用蛋白1抗体
英文名称： Anti-SNIP1/FITC
产品编号： HZ-11260R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： ICC=1:50-200 IF=1:50-200
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Rabbit Anti-SNIP1/FITC Conjugated antibody
FITC标记的Smad核相互作用蛋白1抗体
| 产品编号 | bs-11260R-FITC |
| 英文名称 | Anti-SNIP1/FITC |
| 中文名称 | FITC标记的Smad核相互作用蛋白1抗体 |
| 别 名 | FHA domain-containing protein SNIP1; FLJ12553; Smad nuclear interacting protein (Smad nuclear interacting); Smad nuclear interacting protein; Smad nuclear-interacting protein 1; SNIP1 (Smad nuclear interacting protein); SNIP1; SNIP1_HUMAN; Splicing factor arginine/serine rich 4 (Pre mRNA splicing factor SRP75). |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 信号转导 生长因子和激素 表观遗传学 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Rabbit, Sheep, |
| 产品应用 | ICC=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 46kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human SNIP1 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: Members of the transforming growth factor-beta (TGF-Beta) superfamily play critical roles in controlling cell growth and differentiation. Effects of TGF-Beta family ligands are mediated by Smad proteins. The Smad nuclear interacting protein (SNIP1) contains a forkhead-associated (FHA) domain and acts as a nuclear inhibitor of CBP/p300. SNIP1 potently inhibits the activity of NF-kappa B, which binds the C/H1 domain of CBP/p300, by competing for the binding site. SNIP1 is also thought to induce expression of Cyclin D1 to promote cellular proliferation. SNIP1 is ubiquitously expressed with high expression in heart and skeletal muscle. Function: Down-regulates NF-kappa-B signaling by competing with RELA for CREBBP/EP300 binding. Involved in the microRNA (miRNA) biogenesis. Subunit: Binds SMAD4 and CREBBP/EP300. Binds the SMAD1/OAZ1/PSMB4 complex. Interacts with DROSHA and SMARCA4. Component of the SNARP complex which consists at least of SNIP1, SNW1, THRAP3, BCLAF1 and PNN. Subcellular Location: Nucleus. Tissue Specificity: Tissue specificityUbiquitous, with highest expression in heart and skeletal muscle. Post-translational modifications: Degraded by the proteasome upon binding to the SMAD1/OAZ1/PSMB4 complex. DISEASE: Defects in SNIP1 are the cause of psychomotor retardation, epilepsy, and craniofacial dysmorphism (PMRED) [MIM:614501]. A disease characterized by severe psychomotor retardation, intractable seizures, dysmorphic features, and a lumpy skull surface. Patients are hypotonic and have poor feeding in the neonatal period. Similarity: Contains 1 FHA domain. Database links: UniProtKB/Swiss-Prot: Q8TAD8.1 Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
转化生长因子β（TGF-β）超家族成员在控制细胞生长和分化中起关键作用。TGF-β家族配体的作用是由SMAD蛋白介导的。SMAD核相互作用蛋白（SNIP1）包含叉头相关（FHA）结构域，并作为CBP／P300的核抑制剂。SNIP1有效地抑制NF-κB的活性，其结合CBP／P300的C/H1结构域，通过竞争结合位点。SNIP1也被认为诱导细胞周期蛋白D1的表达促进细胞增殖。SNIP1广泛表达于心脏和骨骼肌中。