Collagen X,Ⅹ型胶原抗体

产品编号HZ-20231R
英文名称Collagen X
中文名称Ⅹ型胶原抗体
别 名Collagen type X; Col10a 1; Collagen alpha 1(X) chain; Collagen type X alpha 1 (Schmid metaphyseal chondrodysplasia); Collagen type X alpha 1; Collagen X alpha 1 polypeptide; CollagenX; fa66d11; fb10c08; OTTHUMP00000040411; Procollagen type X alpha 1; Schmid metaphyseal chondrodysplasia; wu:fa66d11; wu:fb10c08; COAA1_HUMAN; COL10A1; Collagen alpha-1(X) chain; collagen alpha-1(X) chain precursor; Schmid metaphyseal chondrodysplasia; collagen X, alpha-1 polypeptide.
说 明 书0.1ml 0.2ml
研究领域细胞生物 免疫学 细胞骨架 细胞外基质
抗体来源Rabbit
克隆类型Polyclonal
交叉反应Human,
Collagen X,Ⅹ型胶原抗体产品应用WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量73kDa
细胞定位分泌型蛋白
性 状Lyophilized or Liquid
浓 度1mg/1ml
免 疫 原KLH conjugated synthetic peptide derived from human Collagen X
亚 型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
Collagen X,Ⅹ型胶原抗体PubMedPubMed
产品介绍background:
This gene encodes the alpha chain of type X collagen, a short chain collagen expressed by hypertrophic chondrocytes during endochondral ossification. Unlike type VIII collagen, the other short chain collagen, type X collagen is a homotrimer. Mutations in this gene are associated with Schmid type metaphyseal chondrodysplasia (SMCD) and Japanese type spondylometaphyseal dysplasia (SMD). [provided by RefSeq, Jul 2008].

Function:
Type X collagen is a product of hypertrophic chondrocytes and has been localized to presumptive mineralization zones of hyaline cartilage.

Subunit:
Homotrimer.

Subcellular Location:
Secreted, extracellular space, extracellular matrix.

Tissue Specificity:
Prolines at the third position of the tripeptide repeating unit (G-X-Y) are hydroxylated in some or all of the chains.

DISEASE:
Schmid type metaphyseal chondrodysplasia (SMCD) [MIM:156500]: Dominantly inherited disorder of the osseous skeleton. The cardinal features of the phenotype are mild short stature, coxa vara and a waddling gait. Radiography usually shows sclerosis of the ribs, flaring of the metaphyses, and a wide irregular growth plate, especially of the knees. A variant form of SMCD is spondylometaphyseal dysplasia Japanese type. It is characterized by spinal involvement comprising mild platyspondyly, vertebral body abnormalities, and end-plate irregularity. Note=The disease is caused by mutations affecting the gene represented in this entry.

Similarity:
Contains 1 C1q domain.

Gene ID:
1300

Database links:
Entrez Gene: 282416 Cow
Entrez Gene: 1300 Human
Entrez Gene: 12813 Mouse
Entrez Gene: 25681 Rat
Omim: 120110 Human
SwissProt: P23206 Cow
SwissProt: A1L4P2 Human
SwissProt: Q03692 Human

Collagen X,Ⅹ型胶原抗体Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.