FITC标记的粘附分子JAML蛋白抗体
产品名称： FITC标记的粘附分子JAML蛋白抗体
英文名称： Anti-JAML/FITC
产品编号： HZ-17198R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： ICC=1:50-200 IF=1:50-200
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Rabbit Anti-JAML/FITC Conjugated antibody
FITC标记的粘附分子JAML蛋白抗体
| 英文名称 | Anti-JAML/FITC |
| 中文名称 | FITC标记的粘附分子JAML蛋白抗体 |
| 别 名 | adhesion molecule AMICA; Adhesion molecule interacting with CXADR antigen 1; adhesion molecule interacts with CXADR antigen 1; adhesion molecule that interacts with CXADR antigen 1; AMICA; Amica1; CREA7-1; CREA7-4; Dendritic cell-specific protein CREA7-1; dendritic-cell specific protein CREA7-1; dendritic-cell specific protein CREA7-4; FLJ37080; Gm638; JAML1_HUMAN; junctional adhesion molecule; Junctional adhesion molecule-like; Junctional adhesion molecule-like precursor; MGC118814; MGC118815; UNQ722/PRO1387. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 细胞生物 信号转导 细胞粘附分子 细胞类型标志物 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, |
| 产品应用 | ICC=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 43kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human JAML |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: JAML is a 394 amino acid single-pass type I membrane protein and novel adhesion molecule with localization at the cell plasma membrane in regions of cell-to-cell contact but not free cell borders, implying that JAML participates in homophilic interactions. JAML belongs to the immunoglobulin superfamily and is expressed in peripheral blood leukocytes, bone marrow, spleen, lymph nodes and fetal thymus, liver and spleen. JAML assists in the migration of leukocytes through endothelilal and epithelial tissues, mediates binding with CAR (coxsackie and adenovirus receptor) via its Ig-like V-type domain 2, and strengthens the binding of leukocytes to endothelial cells. Consisting of a transmembrane segment, cytoplasmic tail, 19-amino acid signal peptide and two extracellular immunoglobulin-like domains, JAML also undergoes alternative splicing resulting in three isoforms and is encoded by a gene mapping to human chromosome 11q23.3. Function: May function in transmigration of leukocytes through epithelial and endothelial tissues. Expressed at the plasma membrane of polymorphonuclear leukocytes, it mediates adhesive interactions with CXADR, a protein of the junctional complex of epithelial cells. Enhances myeloid leukemia cell adhesion to endothelial cells. Subcellular Location: Cell junction. Cell membrane. Localized at the plasma membrane in areas of cell-cell contacts and at the cell surface of PMN. Tissue Specificity: Expression is restricted to the hematopoietic tissues with the exception of liver. Expressed in fetal liver, spleen and thymus. Similarity: Belongs to the immunoglobulin superfamily. Contains 2 Ig-like V-type (immunoglobulin-like) domains. Database links: Entrez Gene: 120425 Human Entrez Gene: 270152 Mouse Entrez Gene: 315610 Rat Omim: *609770 Human SwissProt: Q86YT9 Human SwissProt: Q80UL9 Mouse Unigene: 16291 Human Unigene: 190461 Mouse Unigene: 21010 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
JAML是一种394个氨基酸的单程I型膜蛋白，是一种新的粘附分子，定位于细胞与细胞接触区域而非游离细胞边界的细胞质膜，提示JAML参与同源相互作用。JAML属于免疫球蛋白超家族，主要表达于外周血白细胞、骨髓、脾脏、淋巴结和胎儿胸腺、肝脏和脾脏。JAML通过内皮和上皮组织帮助白细胞迁移，通过其Ig样V型结构域2介导与CAR的结合，并增强白细胞与内皮细胞的结合。JAML由跨膜片段、胞质尾、19个氨基酸信号肽和两个胞外免疫球蛋白样结构域组成，还经历交替剪接，产生三个亚型，并通过基因定位编码人染色体11q23.3。