FITC标记的甲基固醇羟化酶单加氧酶1抗体
产品名称： FITC标记的甲基固醇羟化酶单加氧酶1抗体
英文名称： Anti-C-4 Methylsterol Oxidase/FITC
产品编号： HZ-2947R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： IF=1:50-200
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Rabbit Anti-C-4 Methylsterol Oxidase/FITC Conjugated antibody
FITC标记的甲基固醇羟化酶单加氧酶1抗体
| 英文名称 | Anti-C-4 Methylsterol Oxidase/FITC |
| 中文名称 | FITC标记的甲基固醇羟化酶单加氧酶1抗体 |
| 别 名 | 1500001G16Rik; C 4 methyl sterol; C78600; DESP4; ERG25; Methylsterol monooxygenase 1; MGC104344; MSMO1; MSMO1_HUMAN; OTTHUMP00000219757; OTTHUMP00000219758; OTTHUMP00000219759; OTTHUMP00000219760; sterol C4 methyl oxidase like. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 肿瘤 心血管 细胞生物 信号转导 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Dog, Cow, Horse, |
| 产品应用 | IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 35kDa |
| 细胞定位 | 细胞膜 |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human ERG25 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: Belonging to the sterol desaturase family, ERG25 is a 293 amino acid enzyme that performs the first of three enzymatic steps required to remove the two methyl groups leading to cholesterol. ERG25 is a multi-pass membrane protein that resides within the plasma membrane and the membrane of the endoplasmic reticulum. Concentrations of ERG25 mRNA increase when subjected to low iron growth conditions, suggesting that the enzyme is not regulated by iron but by an end product of the ergosterol pathway. Low-density lipoprotein (LDL) downregulates ERG25 expression in the vascular wall, an event that may be inhibited via SREBP overexpression. ERG25 is encoded by a gene located on human chromosome 4q32.3. Function: Catalyzes the first step in the removal of the two C-4 methyl groups of 4,4-dimethylzymosterol. Subcellular Location: Endoplasmic reticulum membrane; Multi-pass membrane protein. DISEASE: Microcephaly, congenital cataract, and psoriasiform dermatitis (MCCPD) [MIM:616834]: An autosomal recessive inborn error of cholesterol metabolism characterized by accumulation of a large amount of methylsterols, particularly dimethylsterols, in affected individuals. Patients manifest psoriasiform dermatitis, arthralgias, congenital cataracts, microcephaly, and developmental delay. {ECO:0000269|PubMed:21285510, ECO:0000269|PubMed:24144731}. Note=The disease is caused by mutations affecting the gene represented in this entry. Similarity: Belongs to the sterol desaturase family. Database links: Entrez Gene: 6307 Human Entrez Gene: 66234 Mouse Entrez Gene: 140910 Rat Omim: 607545 Human SwissProt: Q15800 Human SwissProt: Q9CRA4 Mouse SwissProt: O35532 Rat Unigene: 105269 Human Unigene: 30119 Mouse Unigene: 7167 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
属于甾醇脱氢酶家族，Erg25是一种293氨基酸酶，执行三个酶步骤中的第一个，需要除去导致胆固醇的两个甲基组。Erg25是一种多通道膜蛋白，位于质膜和内质网的膜内。在低铁生长条件下，Erg25 mRNA的浓度增加，表明酶不受铁的调节，而是由**甾醇途径的终产物调节。低密度脂蛋白（LDL）下调血管壁中的Erg25表达，这可能通过SREBP过表达抑制。EG25由位于人类染色体4q32.3上的基因编码。