FITC标记的诱捕受体2抗体
产品名称： FITC标记的诱捕受体2抗体
英文名称： Anti-DcR2/FITC
产品编号： HZ-1694R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： Flow-Cyt=1:50-200 ICC=1:50-200 IF=1:50-200
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Rabbit Anti-DcR2/FITC Conjugated antibody
FITC标记的诱捕受体2抗体
| 英文名称 | Anti-DcR2/FITC |
| 中文名称 | FITC标记的诱捕受体2抗体 |
| 别 名 | TNFRSF10D; Decoy receptor 2; CD 264; CD264; CD-264; DcR 2; decoy with truncated death domain; ID; TNF receptor related receptor for TRAIL; TNF related apoptosis inducing ligand receptor 4; TNFRSF 10D; TRAIL R4; TRAIL receptor 4; TRAIL receptor with a truncated death domain; TRAILR4; TRIALR 4; TRUNDD; Tumor necrosis factor receptor superfamily member 10d decoy with truncated death domain; Tumor necrosis factor receptor superfamily member 10D precursor; TR10D_HUMAN. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 肿瘤 细胞生物 免疫学 细胞凋亡 细胞膜受体 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, |
| 产品应用 | Flow-Cyt=1:50-200 ICC=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 36kDa |
| 细胞定位 | 细胞膜 |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human DcR2 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: Apoptosis is induced by certain cytokines including TNF and Fas ligand in the TNF family through their death domain containing receptors. TRAIL/Apo2L, a member of the TNF family, induces apoptosis of a variety of tumor cell lines. DR4 and DR5 are functional receptors for TRAIL, and DcR1/TRID is a decoy receptor. Another member of the TRAIL receptor family was identified and designated DcR2. The DcR2 receptor is 386 amino acids in length and has an extracellular TRAIL binding domain, but lacks intracellular death domain and does not induce apoptosis. Although this receptor binds to the cytotoxic ligand TRAIL, it contains a truncated death domain and functions as an inhibitory receptor. When overexpressed, the DcR2 receptor can protect cells against TRAIL mediated cytotoxicity. Like DR4 and DR5, DcR2 transcript is widely expressed in a variety of normal human tissues but DcR2 is absent in most tumors. Ultraviolet radiation has been shown to upregulate DcR2 expression on human keratinocytes. Over expression of DcR2 attenuated TRAIL induced apoptosis. Function: Receptor for the cytotoxic ligand TRAIL. Contains a truncated death domain and hence is not capable of inducing apoptosis but protects against TRAIL-mediated apoptosis. Reports are contradictory with regards to its ability to induce the NF-kappa-B pathway. According to PubMed:9382840, it cannot but according to PubMed:9430226, it can induce the NF-kappa-B pathway. Subcellular Location: Membrane; Single-pass type I membrane rotein. Tissue Specificity: Widely expressed, in particular in fetal kidney, lung and liver, and in adult testis and liver. Also expressed in peripheral blood leukocytes, colon and small intestine, ovary, prostate, thymus, spleen, pancreas, kidney, lung, placenta and heart. Similarity: Contains 1 death domain. Contains 3 TNFR-Cys repeats. Database links: Entrez Gene: 8793 Human Omim: 603614 Human SwissProt: Q9UBN6 Human Unigene: 213467 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. DcR1因缺乏细胞内信号传导系统而不能传递凋亡信号,但能竞争性与TRAIL（肿瘤坏死因子相关凋亡诱导配体）结合,有干扰凋亡信号的传导作用 |
TNF家族中的某些细胞因子包括TNF和Fas配体，通过含有受体的死亡结构域诱导细胞凋亡。TRAIL／APO2L是肿瘤坏死因子家族成员，诱导多种肿瘤细胞凋亡。DR4和DR5是TRAIL的功能受体，DCR1/TrID是诱饵受体。TRAIL受体家族的另一成员被鉴定并命名为DCR2。DcR2受体长度为386个氨基酸，具有胞外TRAIL结合结构域，但缺乏胞内死亡结构域，不诱导细胞凋亡。虽然这个受体结合的细胞毒性配体TRAIL，它包含截短的死亡域和功能作为一个抑制受体。当过表达时，DCR2受体可保护细胞免受TRAIL介导的细胞毒性。与DR4和DR5一样，DcR2转录物广泛表达于多种正常人体组织，但DcR2在大多数肿瘤中缺失。紫外线辐射已经证明上调角质形成细胞上的DCR2表达。过度表达DCR2减弱TRAIL诱导的细胞凋亡。