FITC标记的G蛋白信号调节蛋白1抗体
产品名称： FITC标记的G蛋白信号调节蛋白1抗体
英文名称： Anti-GPSM1/FITC
产品编号： HZ-7865R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： IF=1:50-200
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Rabbit Anti-GPSM1/FITC Conjugated antibody
FITC标记的G蛋白信号调节蛋白1抗体
| 英文名称 | Anti-GPSM1/FITC |
| 中文名称 | FITC标记的G蛋白信号调节蛋白1抗体 |
| 别 名 | Activator of G-protein signaling 3; AGS3; AGS3 homolog; C10a; G protein signaling modulator 1 (AGS3 like, C. elegans); G-protein-signaling modulator 1; GPSM1; GPSM1_HUMAN. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 细胞生物 发育生物学 神经生物学 信号转导 细胞周期蛋白 G蛋白偶联受体 G蛋白信号 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Horse, Sheep, |
| 产品应用 | IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 75kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human GPSM1 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: Guanine nucleotide dissociation inhibitor (GDI) which functions as a receptor-independent activator of heterotrimeric G-protein signaling. Keeps G(i/o) alpha subunit in its GDP-bound form thus uncoupling heterotrimeric G-proteins signaling from G protein-coupled receptors. Controls spindle orientation and asymmetric cell fate of cerebral cortical progenitors. May also be involved in macroautophagy in intestinal cells. May play a role in drug addiction. Function: Guanine nucleotide dissociation inhibitor (GDI) which functions as a receptor-independent activator of heterotrimeric G-protein signaling. Keeps G(i/o) alpha subunit in its GDP-bound form thus uncoupling heterotrimeric G-proteins signaling from G protein-coupled receptors. Controls spindle orientation and asymmetric cell fate of cerebral cortical progenitors. May also be involved in macroautophagy in intestinal cells. May play a role in drug addiction. Subunit: Interacts with GNAI1, GNAI2 and GNAI3 preferentially in their GDP-bound state. May also interact with GNAO1. Interacts with STK11/LKB1 and MACF1 (By similarity). Interacts with INSC/inscuteable and FRMPD1. Subcellular Location: Cytoplasm, cytosol. Endoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side. Golgi apparatus membrane; Peripheral membrane protein; Cytoplasmic side. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Tissue Specificity: Expressed in intestinal cells. Post-translational modifications: Phosphorylation regulates interaction with G(i/o) alpha. Similarity: Belongs to the GPSM family. Contains 4 GoLoco domains. Contains 9 TPR repeats. Database links: Entrez Gene: 26086 Human Entrez Gene: 67839 Mouse Entrez Gene: 246254 Rat Omim: 609491 Human SwissProt: Q86YR5 Human SwissProt: Q6IR34 Mouse SwissProt: Q9R080 Rat Unigene: 239370 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
鸟嘌呤核苷酸解离抑制剂（GDI）作为一种与受体无关的异源三聚体G蛋白信号激活因子。保持G（I/O）α亚基以其GDP结合形式，从而解偶联G蛋白偶联受体的异三聚体G蛋白信号。控制大脑皮质祖细胞的纺锤体定向和不对称细胞命运。也可能参与肠道细胞的巨自噬作用。可能在药物成瘾中起作用。