FITC标记的顺氯氨铂耐药相关蛋白9抗体
产品名称： FITC标记的顺氯氨铂耐药相关蛋白9抗体
英文名称： Anti-CRR9/FITC
产品编号： HZ-6797R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： ICC=1:50-200 IF=1:50-200
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Rabbit Anti-CRR9/FITC Conjugated antibody
FITC标记的顺氯氨铂耐药相关蛋白9抗体
| 英文名称 | Anti-CRR9/FITC |
| 中文名称 | FITC标记的顺氯氨铂耐药相关蛋白9抗体 |
| 别 名 | Cisplatin resistance related protein 9; Cisplatin resistance related protein CRR9p; Cisplatin resistance-related protein 9; Cleft lip and palate transmembrane protein 1 like protein; Cleft lip and palate transmembrane protein 1-like protein; CLP1L_HUMAN; CLPTM1 like; CLPTM1 like protein; CLPTM1-like protein; CLPTM1L; CRR9; CRR9p. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 肿瘤 细胞生物 细胞凋亡 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Dog, Horse, |
| 产品应用 | ICC=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 62kDa |
| 细胞定位 | 细胞膜 |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human CLPTM1L/CRR9 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: Clefts of the oral-facial region usually occur in early fetal development and can affect the lip, the soft palate and the hard palate. Cleft lip (with or without cleft palate) is a genetically complex birth defect that occurs in approximately one in every 750-1,000 live births. This is one of the most common birth defects and is multifactorial, with both genetic and environmental causes. Cleft lip- and palate-associated transmembrane protein 1 (CLPTM1) belongs to a family of cleft lip and palate transmembrane proteins. This family also contains cisplatin resistance-related protein (CRR9), which is involved in CDDP-induced apoptosis. CLPTM1L (cleft lip and palate transmembrane protein 1-like protein), also known as CRR9p (cisplatin resistance-related protein 9) is a 538 amino acid multi-pass membrane protein that belongs to the CLPTM1 family and, when overexpressed, enhances cisplatin-mediated apoptosis. CLPTM1L exists as two alternatively spliced isoforms encoded by a gene that maps to human chromosome 5p15.33. Function: Enhances cisplatin-mediated apoptosis, when overexpressed. Subcellular Location: Membrane; Multi-pass membrane protein (Potential). Similarity: Belongs to the CLPTM1 family Database links: Entrez Gene: 81037 Human Omim: 612585 Human SwissProt: Q96KA5 Human Unigene: 444673 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 顺氯氨铂属于细胞周期非特异性药物，具有细胞毒性，可抑制癌细胞的DNA复制过程，并损伤其细胞膜上结构，有较强的广谱抗癌作用。临床用于卵巢癌、前列腺癌、睾丸癌、肺癌、鼻咽癌、食道癌、恶性淋巴瘤、乳腺癌、头颈部鳞癌、甲状腺癌及成骨肉瘤等多种实体肿瘤均能显示疗效 |
口腔面部的裂口通常发生在胎儿早期发育过程中，可影响唇、软腭和硬腭。唇裂（有或没有腭裂）是一种遗传复杂的出生缺陷，大约每750-1000个活产儿中有一个发生。这是一种最常见的出生缺陷，是多因素的，有遗传和环境的原因。唇腭裂相关跨膜蛋白1（CLTPM1）属于唇腭裂跨膜蛋白家族。该家族还含有顺铂耐药相关蛋白（CRR9），参与CDDP诱导的细胞凋亡。CLPTM1L（唇腭裂跨膜蛋白1样蛋白），又称CRR9P（顺铂耐药相关蛋白9），是属于CLTPM1家族的538氨基酸多通道膜蛋白，当过表达时，增强顺铂介导的细胞凋亡。CLTPM1L存在于由人类染色体5p1533所编码的基因编码的两个交替拼接的异构体中。