CLEC9A,C型凝集素结构域家族9成员A抗体

产品编号HZ-13621R
英文名称CLEC9A
中文名称C型凝集素结构域家族9成员A抗体
别 名C type lectin domain family 9, member A; C-type lectin domain family 9 member A; CLC9A_MOUSE; CLEC9A; DNGR1; HEEE9341; PRO34046; UNQ9341.
说 明 书0.1ml 0.2ml
研究领域细胞生物 信号转导 干细胞 细胞粘附分子
抗体来源Rabbit
克隆类型Polyclonal
交叉反应Mouse, Rat,
CLEC9A,C型凝集素结构域家族9成员A抗体产品应用WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量27kDa
细胞定位细胞膜
性 状Lyophilized or Liquid
浓 度1mg/1ml
免 疫 原KLH conjugated synthetic peptide derived from mouse CLEC9A
亚 型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
CLEC9A,C型凝集素结构域家族9成员A抗体PubMedPubMed
产品介绍background:
The C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily consists of a variety of proteins that share a common protein fold and have diverse functions, including cell-cell signaling, cell adhesion, glycoprotein turnover and immune responses. CLEC-9A (C-type lectin domain family 9 member A), also known as DNGR1 (dendritic cell natural killer lectin group receptor 1), is a 241 amino acid single-pass type II membrane protein that contains one C-type lectin domain and belongs to the CTL/CTLD superfamily. Expressed in myeloid lineage cells, brain, spleen and thymus, CLEC-9A is a group V C-type lectin-like receptor (CTLR) that acts as an activation receptor. The gene encoding CLEC-9A maps to human chromosome 12p13.2 and mouse chromosome 6 F3.

Function:
Functions as an endocytic receptor on a small subset of myeloid cells specialized for the uptake and processing of material from dead cells. Recognizes filamentous form of actin in association with particular actin-binding domains of cytoskeletal proteins, including spectrin, exposed when cell membranes are damaged, and mediate the cross-presentation of dead-cell associated antigens in a Syk-dependent manner.

Subcellular Location:
Membrane.

Tissue Specificity:
In peripheral blood highly restricted on the surface of BDCA31(+) dendritic cells and on a small subset of CD14(+) and CD16(-) monocytes.

Post-translational modifications:
N-glycosylated.

Similarity:
Contains 1 C-type lectin domain.

Gene ID:
232414

CLEC9A,C型凝集素结构域家族9成员A抗体Database links:
Entrez Gene: 232414 Mouse
SwissProt: Q8BRU4 Mouse
Unigene: 391518 Mouse

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.